An emerging opportunistic infection: fatal astrovirus (VA1/HMO-C) encephalitis in a pediatric stem cell transplant recipient

被引：64

作者：

Lum, Su Han ^{[1
]}

Turner, Andrew ^{[2
]}

Guiver, Malcolm ^{[2
]}

Bonney, Denise ^{[1
]}

Martland, Timorthy ^{[3
]}

Davies, Emma ^{[2
]}

Newbould, Melanie ^{[4
]}

Brown, Julianne ^{[5
]}

Morfopoulou, Sofia ^{[6
]}

Breuer, Judith ^{[6
]}

Wynn, Robert ^{[1
]}

机构：

[1] Royal Manchester Childrens Hosp, Dept Blood & Marrow Transplant, Oxford Rd, Manchester M13 9WL, Lancs, England

[2] Manchester Royal Infirm, Dept Clin Virol, Manchester, Lancs, England

[3] Royal Manchester Childrens Hosp, Dept Neurol, Manchester, Lancs, England

[4] Royal Manchester Childrens Hosp, Diagnost Paediat Histopathol Serv, Manchester, Lancs, England

[5] Great Ormond St Hosp Sick Children, Microbiol Virol & Infect Prevent & Control, London, England

[6] UCL, Div Infect & Immun, Res Dept Infect, London, England

来源：

TRANSPLANT INFECTIOUS DISEASE | 2016年 / 18卷 / 06期

关键词：

astrovirus VA1-HMO-C; BMT; deep brain sequencing; unexplained encephalitis;

D O I：

10.1111/tid.12607

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinvasive astrovirus (VA1-HMO-C) is an emerging life-threatening infection in immunocompromised hosts. We describe an 8-month-old child who died of VA1/HMO-C encephalitis following bone marrow transplantation. The diagnosis was only made post-mortem using RNA deep sequencing of the brain. Repeat analysis of the post-mortem brain tissue using polymerase chain reaction specific primers for VA1/HMO-C was positive. Astrovirus VA1/HMO-C should be included in the evaluation of patients with similar encephalitis.

引用

页码：960 / 964

页数：5

共 10 条

[1] Consensus guidelines for the investigation and management of encephalitis in adults and children in Australia and New Zealand [J].

Britton, P. N. ;

Eastwood, K. ;

Paterson, B. ;

Durrheim, D. N. ;

Dale, R. C. ;

Cheng, A. C. ;

Kenedi, C. ;

Brew, B. J. ;

Burrow, J. ;

Nagree, Y. ;

Leman, P. ;

Smith, D. W. ;

Read, K. ;

Booy, R. ;

Jones, C. A. .

INTERNAL MEDICINE JOURNAL, 2015, 45 (05) :563-576

[2] Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients [J].

Brown, Julianne R. ;

Morfopoulou, Sofia ;

Hubb, Jonathan ;

Emmett, Warren A. ;

Ip, Winnie ;

Shah, Divya ;

Brooks, Tony ;

Paine, Simon M. L. ;

Anderson, Glenn ;

Virasami, Alex ;

Tong, C. Y. William ;

Clark, Duncan A. ;

Plagnol, Vincent ;

Jacques, Thomas S. ;

Qasim, Waseem ;

Hubank, Mike ;

Breuer, Judith .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (06) :881-888

[3] Serological Studies Confirm the Novel Astrovirus HMOAstV-C as a Highly Prevalent Human Infectious Agent [J].

Burbelo, Peter D. ;

Ching, Kathryn H. ;

Esper, Frank ;

Iadarola, Michael J. ;

Delwart, Eric ;

Lipkin, W. Ian ;

Kapoor, Amit .

PLOS ONE, 2011, 6 (08)

[4] Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis [J].

Fremond, M. -L. ;

Perot, P. ;

Muth, E. ;

Cros, G. ;

Dumarest, M. ;

Mahlaoui, N. ;

Seilhean, D. ;

Desguerre, I. ;

Hebert, C. ;

Corre-Catelin, N. ;

Neven, B. ;

Lecuit, M. ;

Blanche, S. ;

Picard, C. ;

Eloit, M. .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2015, 4 (03) :E53-E57

[5] Beyond viruses: Clinical profiles and etiologies associated with encephalitis [J].

Glaser, C. A. ;

Honarmand, S. ;

Anderson, L. J. ;

Schnurr, D. P. ;

Forghani, B. ;

Cossen, C. K. ;

Schuster, F. L. ;

Christie, L. J. ;

Tureen, J. H. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (12) :1565-1577

[6] Multiple novel astrovirus species in human stool [J].

Kapoor, A. ;

Li, L. ;

Victoria, J. ;

Oderinde, B. ;

Mason, C. ;

Pandey, P. ;

Zaidi, S. Z. ;

Delwart, E. .

JOURNAL OF GENERAL VIROLOGY, 2009, 90 :2965-2972

[7] Bayesian mixture analysis for metagenomic community profiling [J].

Morfopoulou, Sofia ;

Plagnol, Vincent .

BIOINFORMATICS, 2015, 31 (18) :2930-2938

[8] Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing [J].

Naccache, Samia N. ;

Peggs, Karl S. ;

Mattes, Frank M. ;

Phadke, Rahul ;

Garson, Jeremy A. ;

Grant, Paul ;

Samayoa, Erik ;

Federman, Scot ;

Miller, Steve ;

Lunn, Michael P. ;

Gant, Vanya ;

Chiu, Charles Y. .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (06) :919-923

[9] Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia [J].

Quan, Phenix-Lan ;

Wagner, Thor A. ;

Briese, Thomas ;

Torgerson, Troy R. ;

Hornig, Mady ;

Tashmukhamedova, Alla ;

Firth, Cadhla ;

Palacios, Gustavo ;

Baisre-De-Leon, Ada ;

Paddock, Christopher D. ;

Hutchison, Stephen K. ;

Egholm, Michael ;

Zaki, Sherif R. ;

Goldman, James E. ;

Ochs, Hans D. ;

Lipkin, W. Ian .

EMERGING INFECTIOUS DISEASES, 2010, 16 (06) :918-925

[10] Encephalitis in children [J].

Thompson, Clara ;

Kneen, Rachel ;

Riordan, Andrew ;

Kelly, Dominic ;

Pollard, Andrew J. .

ARCHIVES OF DISEASE IN CHILDHOOD, 2012, 97 (02) :150-161

← 1 →