Dopamine Transporter SPECT/CT and Perfusion Brain SPECT Imaging in Idiopathic Basal Ganglia Calcinosis

被引：17

作者：

Paschali, Anna ^{[1
]}

Lakiotis, Velissarios

Messinis, Lambros ^{[2
]}

Markaki, Elli ^{[2
]}

Constantoyannis, Constantine ^{[2
]}

Ellul, John ^{[2
]}

Vassilakos, Pavlos

机构：

[1] Gen Univ Hosp Patras, Med Sch Patras, Dept Nucl Med, Patras 26500, Greece

[2] Patras Med Sch, Dept Neurol, Neuropsychol Sect, Patras, Greece

来源：

CLINICAL NUCLEAR MEDICINE | 2009年 / 34卷 / 07期

关键词：

SPECT/CT; dopamine transporter; idiopathic basal ganglia calcification; BILATERAL STRIOPALLIDODENTATE CALCINOSIS; FAHRS-DISEASE; CALCIFICATION; TOMOGRAPHY;

D O I：

10.1097/RLU.0b013e3181a7d195

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A case of idiopathic basal ganglia calcification in a 56-year-old woman with parkinsonism and cognitive impairment is described. The nigrostriatal dopaminergic pathway and regional cerebral blood flow were evaluated using dopamine transporter (DAT) brain single photon emission tomography combined with a low-dose x-ray computerized tomography transmission (hybrid SPECT/CT) and Tc-99m HMPAO brain perfusion SPECT study, respectively. DAT SPECT/CT imaging revealed a reduction in DAT binding in both striatum regions coinciding with bilateral calcifications in the basal ganglia. Brain perfusion scan showed hypoperfusion in basal ganglia regions, posterior parietal cortex bilaterally, left frontopolar and dorsolateral prefrontal cortex, and left temporal lobe. These findings correlated well with the clinical condition of the patient. Mineralization may play a critical role in the pathogenesis of neuronal degeneration. Cortical perfusion changes in patients may better explain the patient's altered cognitive and motor functions.

引用

页码：421 / 423

页数：3

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