Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations

被引：10

作者：

Holzer, Wolfgang ^{[1
]}

Eller, Gernot A. ^{[1
]}

Datterl, Barbara ^{[1
]}

Habicht, Daniela ^{[1
]}

机构：

[1] Univ Vienna, Dept Drug & Nat Prod Synth, Fac Life Sci, A-1090 Vienna, Austria

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2009年 / 47卷 / 07期

关键词：

NMR; H-1; C-13; N-15; pyrazines; NUCLEAR-MAGNETIC-RESONANCE; CHEMICAL-SHIFTS; 2,3-DISUBSTITUTED PYRAZINES; MONOSUBSTITUTED PYRAZINES; COUPLING-CONSTANTS; RING-SYSTEMS; N-OXIDES; SPECTRA; 2-CHLOROPYRAZINE; CYANATION;

D O I：

10.1002/mrc.2437

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR spectroscopic studies are undertaken with derivatives of 2-pyrazinecarboxylic acid. Complete and unambiguous assignment of chemical shifts (H-1, C-13, N-15) and coupling constants (H-1, H-1; C-13, H-1; N-15, H-1) is achieved by combined application of various 1D and 2D NMR spectroscopic techniques. Unequivocal mapping of C-13, H-1 spin coupling constants is accomplished by 2D (delta,J) long-range INEPT spectra with selective excitation. Phenomena such as the tautomerism of 3-hydroxy-2-pyrazinecarboxylic acid are discussed. Copyright (c) 2009 John Wiley & Sons, Ltd.

引用

页码：617 / 624

页数：8

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