Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations

被引:9
作者
Holzer, Wolfgang [1 ]
Eller, Gernot A. [1 ]
Datterl, Barbara [1 ]
Habicht, Daniela [1 ]
机构
[1] Univ Vienna, Dept Drug & Nat Prod Synth, Fac Life Sci, A-1090 Vienna, Austria
关键词
NMR; H-1; C-13; N-15; pyrazines; NUCLEAR-MAGNETIC-RESONANCE; CHEMICAL-SHIFTS; 2,3-DISUBSTITUTED PYRAZINES; MONOSUBSTITUTED PYRAZINES; COUPLING-CONSTANTS; RING-SYSTEMS; N-OXIDES; SPECTRA; 2-CHLOROPYRAZINE; CYANATION;
D O I
10.1002/mrc.2437
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
NMR spectroscopic studies are undertaken with derivatives of 2-pyrazinecarboxylic acid. Complete and unambiguous assignment of chemical shifts (H-1, C-13, N-15) and coupling constants (H-1, H-1; C-13, H-1; N-15, H-1) is achieved by combined application of various 1D and 2D NMR spectroscopic techniques. Unequivocal mapping of C-13, H-1 spin coupling constants is accomplished by 2D (delta,J) long-range INEPT spectra with selective excitation. Phenomena such as the tautomerism of 3-hydroxy-2-pyrazinecarboxylic acid are discussed. Copyright (c) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:617 / 624
页数:8
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