Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies

被引：36

作者：

Almangush, Alhadi ^{[1
,2
,3
]}

Leivo, Ilmo ^{[4
]}

Siponen, Maria ^{[5
,6
,7
]}

Sundquist, Elias ^{[5
,8
]}

Mroueh, Rayan ^{[9
,10
]}

Makitie, Antti A. ^{[9
,10
]}

Soini, Ylermi ^{[11
,12
]}

Haglund, Caj ^{[13
,14
,15
]}

Nieminen, Pentti ^{[16
]}

Salo, Tuula ^{[2
,5
,8
,10
,17
]}

机构：

[1] Univ Helsinki, Dept Pathol, Helsinki, Finland

[2] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland

[3] Univ Misurata, Inst Dent, Misurata, Libya

[4] Univ Turku, Dept Pathol, Turku, Finland

[5] Univ Oulu, Canc & Translat Med Res Unit, Oulu, Finland

[6] Kuopio Univ Hosp, Dept Oral & Maxillofacial Dis, Kuopio, Finland

[7] Univ Eastern Finland, Inst Dent, Kuopio, Finland

[8] Oulu Univ Hosp, Med Res Ctr, Oulu, Finland

[9] Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[10] Univ Helsinki, Helsinki, Finland

[11] Univ Eastern Finland, Dept Pathol & Forens Med, Kuopio, Finland

[12] Canc Ctr Eastern Finland, Kuopio, Finland

[13] Univ Helsinki, Dept Surg, Helsinki, Finland

[14] Helsinki Univ Hosp, Helsinki, Finland

[15] Univ Helsinki, Res Programs Unit, Translat Canc Biol, Helsinki, Finland

[16] Univ Oulu, Med Informat & Stat Res Grp, Oulu, Finland

[17] Univ Helsinki, Cent Hosp, Dept Pathol, HUSLAB, Helsinki, Finland

来源：

VIRCHOWS ARCHIV | 2018年 / 472卷 / 02期

关键词：

Oral tongue cancer; Tumor budding; Tumor depth; BD model; Prognosis; SQUAMOUS-CELL CARCINOMA; TUMOR THICKNESS; PROGNOSTIC VALUE; POOR-PROGNOSIS; WORST PATTERN; STAGE; METASTASIS; EXPRESSION; METAANALYSIS; INVOLVEMENT;

D O I：

10.1007/s00428-017-2212-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

It is of great clinical importance to identify simple prognostic markers from preoperative biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth of invasion (D), and the combined scores (i.e., budding and depth of invasion (BD) histopathologic model) in preoperative biopsies and the corresponding postoperative specimens of oral tongue squamous cell carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre- and postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity statistics were used. Our results showed statistically significant (P < 0.001) relationship between pre- and postoperative BD scores. There was an agreement between the pre- and postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI 39.4 to 73.7%) and 96.9% specificity (95% CI 89.3 to 99.6%). Our findings suggest that the BD model, analyzed from representative biopsies, could be used for the treatment planning of OTSCC.

引用

页码：231 / 236

页数：6

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Ilmo Leivo
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