Resistance to Antimalarial Drugs: Molecular, Pharmacologic, and Clinical Considerations

被引：31

作者：

Travassos, Mark A. ^{[1
]}

Laufer, Miriam K. ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA

来源：

PEDIATRIC RESEARCH | 2009年 / 65卷 / 05期

关键词：

PLASMODIUM-FALCIPARUM MALARIA; ARTEMETHER-LUMEFANTRINE; IN-VITRO; PYRIMETHAMINE-SULFADOXINE; ARTESUNATE-MEFLOQUINE; POINT MUTATIONS; CHLOROQUINE; EFFICACY; ARTEMISININ; PFMDR1;

D O I：

10.1203/PDR.0b013e3181a0977e

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

One of the greatest obstacles to the control of malaria has been the spread of resistance to drugs used on a large scale. This review provides an update of the current understanding of the molecular basis for antimalarial drug resistance. Parasite intrinsic resistance is just one component that determines the in vivo efficacy of a drug. Human immune responses and pharmacologic properties play important roles in determining the clinical outcome of treatment. The emergence and spread of resistance also results' from an interplay of these factors. Current efforts to characterize and deter resistance to new combination therapy are also discussed. (Pediatr Res 65: 64R-70R, 2009)

引用

页码：64R / 70R

页数：7

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