Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications

被引：81

作者：

Bober, Josef R. ^{[1
]}

Beisel, Chase L. ^{[2
]}

Nair, Nikhil U. ^{[1
]}

机构：

[1] Tufts Univ, Dept Chem & Biol Engn, Medford, MA 02155 USA

[2] North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 20 | 2018年 / 20卷

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

probiotics; genetic tools; CRISPR; genome engineering; microbiome; LACTIC-ACID BACTERIA; HETEROLOGOUS PROTEIN SECRETION; GENE-EXPRESSION SYSTEM; ESCHERICHIA-COLI; LACTOBACILLUS-REUTERI; LACTOCOCCUS-LACTIS; GUT MICROBIOTA; ANTIMICROBIAL PEPTIDES; IN-VIVO; BIFIDOBACTERIUM-LONGUM;

D O I：

10.1146/annurev-bioeng-062117-121019

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies.

引用

页码：277 / 300

页数：24

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