Use of recombinant factor VIIa prior to lumbar puncture in pediatric patients with acute leukemia

被引：7
作者：
Das, Prabodh [1 ]
Carcao, Manuel [1 ]
Hitzler, Johann [1 ]
机构：
[1] Univ Toronto, Div Hematol Oncol, Hosp Sick Children, Dept Pediat, Toronto, ON M5G 1X8, Canada
来源：
PEDIATRIC BLOOD & CANCER | 2006年 / 47卷 / 02期
关键词：
hemorrhage; lumbar; pediatric acute leukemia; prophylaxis; puncture; recombinant activated factor VII;
D O I：
10.1002/pbc.20467
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The persistence of abnormal coagulation test results after standard treatment with fresh frozen plasma (FFP) poses significant problems in children with acute leukemia requiring a diagnostic lumbar puncture and intrathecal chemotherapy. We report the prophylactic use of a single dose of 90 mu g/kg recombinant activated factor VII (rFVIIa) in three children and the rapid correction of abnormal coagulation test results previously not corrected by FFP. Administration of rFVIIa was useful in avoiding a delay of diagnostic lumbar punctures and intrathecal chemotherapy. Hemorrhagic complications and adverse effects of rFVIIa were not observed. Prospective evaluation of this indication and dose appears warranted.
引用
收藏
页码：206 / 209
页数：4
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