The Ecstasy and Agony of Assay Interference Compounds

被引：109
作者：
Aldrich, Courtney
Bertozzi, Carolyn
Georg, Gunda I.
Kiessling, Laura
Lindsley, Craig
Liotta, Dennis
Merz, Kenneth M., Jr.
Schepartz, Alanna
Wang, Shaomeng
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 60卷 / 06期
关键词：
HIGH-THROUGHPUT; COMPOUNDS PAINS; AGGREGATION; INHIBITORS; DISCOVERY; FLAVONOIDS; SCREENS; DOCKING; DRUGS; HITS;
D O I：
10.1021/acs.jmedchem.7b00229
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：2165 / 2168
页数：4
相关论文
共 42 条
  • [1] Small molecule inhibitors of HIVgp41 N-heptad repeat trimer formation
    Allen, William J.
    Yi, Hyun Ah
    Gochin, Miriam
    Jacobs, Amy
    Rizzo, Robert C.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (14) : 2853 - 2859
  • [2] The promise and peril of chemical probes
    Arrowsmith, Cheryl H.
    Audia, James E.
    Austin, Christopher
    Baell, Jonathan
    Bennett, Jonathan
    Blagg, Julian
    Bountra, Chas
    Brennan, Paul E.
    Brown, Peter J.
    Bunnage, Mark E.
    Buser-Doepner, Carolyn
    Campbell, Robert M.
    Carter, Adrian J.
    Cohen, Philip
    Copeland, Robert A.
    Cravatt, Ben
    Dahlin, Jayme L.
    Dhanak, Dashyant
    Edwards, Aled M.
    Frye, Stephen V.
    Gray, Nathanael
    Grimshaw, Charles E.
    Hepworth, David
    Howe, Trevor
    Huber, Kilian V. M.
    Jin, Jian
    Knapp, Stefan
    Kotz, Joanne D.
    Kruger, Ryan G.
    Lowe, Derek
    Mader, Mary M.
    Marsden, Brian
    Mueller-Fahrnow, Anke
    Mueller, Susanne
    O'Hagan, Ronan C.
    Overington, John P.
    Owen, Dafydd R.
    Rosenberg, Saul H.
    Roth, Brian
    Ross, Ruth
    Schapira, Matthieu
    Schreiber, Stuart L.
    Shoichet, Brian
    Sundstrom, Michael
    Superti-Furga, Giulio
    Taunton, Jack
    Toledo-Sherman, Leticia
    Walpole, Chris
    Walters, Michael A.
    Willson, Timothy M.
    [J]. NATURE CHEMICAL BIOLOGY, 2015, 11 (08) : 536 - 541
  • [3] Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase
    Babaoglu, Kerim
    Simeonov, Anton
    Lrwin, John J.
    Nelson, Michael E.
    Feng, Brian
    Thomas, Craig J.
    Cancian, Laura
    Costi, M. Paola
    Maltby, David A.
    Jadhav, Ajit
    Inglese, James
    Austin, Christopher P.
    Shoichet, Brian K.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (08) : 2502 - 2511
  • [4] Chemical con artists foil drug discovery
    Baell, Jonathan
    Walters, Michael A.
    [J]. NATURE, 2014, 513 (7519) : 481 - 483
  • [5] Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
    Baell, Jonathan B.
    [J]. JOURNAL OF NATURAL PRODUCTS, 2016, 79 (03): : 616 - 628
  • [6] Screening-Based Translation of Public Research Encounters Painful Problems
    Baell, Jonathan B.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (03): : 229 - 234
  • [7] Baell JB, 2010, FUTURE MED CHEM, V2, P1529, DOI [10.4155/fmc.10.237, 10.4155/FMC.10.237]
  • [8] New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
    Baell, Jonathan B.
    Holloway, Georgina A.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (07) : 2719 - 2740
  • [9] Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
    Bisson, Jonathan
    McAlpine, James B.
    Friesen, J. Brent
    Chen, Shao-Nong
    Graham, James
    Pauli, Guido F.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (05) : 1671 - 1690
  • [10] Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase
    Brecher, Matthew
    Chen, Hui
    Liu, Binbin
    Banavali, Nilesh K.
    Jones, Susan A.
    Zhang, Jing
    Li, Zhong
    Kramer, Laura D.
    Li, Hongmin
    [J]. PLOS ONE, 2015, 10 (06):
12345