A drug delivery system based on switchable photo-controlled p-coumaric acid derivatives anchored on mesoporous silica

被引：33

作者：

Benova, Eva ^{[1
]}

Zelenak, Vladimir ^{[1
]}

Halamova, Dasa ^{[1
]}

Almasi, Miroslav ^{[1
]}

Petrul'ova, Veronika ^{[2
]}

Psotka, Miroslav ^{[1
]}

Zelenakova, Adriana ^{[3
]}

Backor, Martin ^{[2
]}

Hornebecq, Virginie ^{[4
]}

机构：

[1] Safarik Univ, Inst Chem, Fac Sci, Moyzesova 11, SK-04154 Kosice, Slovakia

[2] Safarik Univ, Inst Biol & Ecol, Fac Sci, Manesova 23, SK-04154 Kosice, Slovakia

[3] Safarik Univ, Inst Phys, Fac Sci, Pk Angelinum 9, SK-04154 Kosice, Slovakia

[4] Aix Marseille Univ, CNRS, MADIREL, Marseille, France

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 04期

关键词：

CONTROLLED-RELEASE; NANOPARTICLES; ULTRASOUND;

D O I：

10.1039/c6tb02040b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A stimuli-responsive drug delivery system consisting of mesoporous silica with its surface modified by p-coumaric acid derivatives (CA) as photo-switchable ligands was studied for the delivery of the non-steroidal anti-inflammatory drug (NSAID) naproxen. For this purpose, MCM-41 mesoporous silica material was prepared and post-synthetically modified by the grafting of a triethoxysilyl derivative of p-coumaric acid, which undergoes a reversible photo-dimerization under UV irradiation and creates the "valves'' on the surface of silica allowing targeted opening/closing of the pores. Naproxen was encapsulated into grafted MCM-41 and drug release studies were performed in two different media, in a simulated gastric fluid (pH = 2) and in a simulated body fluid (pH = 7.4). Differences in drug release were observed after irradiation of the material using UV light at lambda = 365 nm (closed pore configuration) and UV light at lambda = 254 nm (opened pore configuration).

引用

页码：817 / 825

页数：9

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