Vaccine Technologies Against Avian Influenza: Current Approaches and New Directions

被引:9
作者
Ross, Kathleen A. [1 ]
Huntimer, Lucas M. [2 ]
Ramirez, Julia E. Vela [1 ]
Adams, Justin R. [1 ]
Carpenter, Susan L. [3 ]
Kohut, Marian L. [4 ]
Bronich, Tatiana [5 ]
Webby, Richard [6 ]
Legge, Kevin L. [7 ]
Mallapragada, Surya K. [1 ]
Wannemuehler, Michael J. [2 ]
Narasimhan, Balaji [1 ]
机构
[1] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA
[2] Iowa State Univ, Dept Vet Microbiol & Prevent Med, Ames, IA 50011 USA
[3] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA
[4] Iowa State Univ, Dept Kinesiol, Ames, IA 50011 USA
[5] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE 68198 USA
[6] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[7] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
关键词
H5N1; Highly Pathogenic Avian Influenza; Pandemic; Vaccine; Antiviral; VIRUS-LIKE-PARTICLES; T-CELL RESPONSES; REACTIVE IMMUNE-RESPONSES; PRIME-BOOST VACCINATION; AGE-RELATED DEFECTS; 2009 PANDEMIC H1N1; B SURFACE-ANTIGEN; H5N1; INFLUENZA; A H5N1; DENDRITIC CELLS;
D O I
10.1166/jbn.2014.1983
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The potential epidemiological human pandemic resulting from highly pathogenic avian influenza (HPAI) H5N1 has been studied extensively since the identification of the virus in the Guangdong province of China. The majority of research has focused on the unique and severe histopathological lesions induced by the virus. The severe pathological presentation of these infections has also prompted interest in identifying preventive and therapeutic approaches against HPAI. The potential severity of a HPAI pandemic and the efforts to identify effective intervention strategies have led to many novel discoveries in vaccine and antiviral development that are critically examined in this review.
引用
收藏
页码:2261 / 2294
页数:34
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