Incidence, Prevention, and Treatment of Parenteral Nutrition-Associated Cholestasis and Intestinal Failure-Associated Liver Disease in Infants and Children: A Systematic Review

被引:150
作者
Lauriti, Giuseppe [1 ,2 ]
Zani, Augusto [1 ]
Aufieri, Roberto [1 ]
Cananzi, Mara [1 ]
Chiesa, Pierluigi Lelli [2 ]
Eaton, Simon [1 ]
Pierro, Agostino [3 ]
机构
[1] UCL Inst Child Hlth, Dept Surg, London, England
[2] Univ G DAnnunzio, Dept Paediat Surg, Chieti, Italy
[3] Hosp Sick Children, Div Gen & Thorac Surg, Toronto, ON M5G 1X8, Canada
关键词
parenteral nutrition; intestinal failure; cholestasis; liver disease; child; SHORT-BOWEL SYNDROME; RANDOMIZED CONTROLLED-TRIAL; MEDIUM-CHAIN TRIGLYCERIDES; DOSE ORAL ERYTHROMYCIN; BIRTH-WEIGHT INFANTS; FISH-OIL; URSODEOXYCHOLIC ACID; LIPID EMULSION; PREMATURE-INFANTS; MULTIVARIATE-ANALYSIS;
D O I
10.1177/0148607113496280
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Cholestasis is a significant life-threatening complication in children on parenteral nutrition (PN). Strategies to prevent/treat PN-associated cholestasis (PNAC) and intestinal failure-associated liver disease (IFALD) have reached moderate success with little supporting evidence. Aims of this systematic review were (1) to determine the incidence of PNAC/IFALD in children receiving PN for 14 days and (2) to review the efficacy of measures to prevent/treat PNAC/IFALD. Methods: Of 4696 abstracts screened, 406 relevant articles were reviewed, and studies on children with PN 14 days and cholestasis (conjugated bilirubin 2 mg/dL) were included. Analyzed parameters were (1) PNAC/IFALD incidence by decade and by PN length and (2) PNAC/IFALD prevention and treatment (prospective studies). Results: Twenty-three articles (3280 patients) showed an incidence of 28.2% and 49.8% of PNAC and IFALD, respectively, with no evident alteration over the last decades. The incidence of PNAC was directly proportional to the length of PN (from 15.7% for PN 1 month up to 60.9% for PN 2 months; P < .0001). Ten studies on PNAC met inclusion criteria. High or intermediate-dose of oral erythromycin and aminoacid-free PN with enteral whey protein gained significant benefits in preterm neonates (P < .05, P = .003, and P < .001, respectively). None of the studies reviewed met inclusion criteria for treatment. Conclusions: The incidence of PNAC/IFALD in children has no obvious decrease over time. PNAC is directly correlated to the length of PN. Erythromycin and aminoacid-free PN with enteral whey protein have shown to prevent PNAC in preterm neonates. There is a lack of high-quality prospective studies, especially on IFALD.
引用
收藏
页码:70 / 85
页数:16
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