Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma

被引：102
|
作者：
Yuan, Sheng-Xian [1 ]
Tao, Qi-Fei [1 ]
Wang, Jie [3 ]
Yang, Fu [2 ]
Liu, Lei [3 ]
Wang, Li-Li [1 ]
Zhang, Jin [1 ]
Yang, Yuan [1 ]
Liu, Hui [1 ]
Wang, Fang [2 ]
Sun, Shu-Han [2 ]
Zhou, Wei-Ping [1 ]
机构：
[1] Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Hepat Surg 3, Shanghai, Peoples R China
[2] Second Mil Med Univ, Dept Med Genet, Shanghai, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai, Peoples R China
来源：
CANCER LETTERS | 2014年 / 349卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Antisense RNA; Long noncoding RNA; Tumor growth; RNA hybridazation; RNA stability; DNA-REPLICATION; EXPRESSION; CANCER; P53; HEPATECTOMY; ENHANCER;
D O I：
10.1016/j.canlet.2014.03.029
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
About 61-72% of transcribed regions possess long noncoding RNAs in antisense orientation (Antisense long noncoding RNAs, asIncRNAs). However, the function of aslncRNAs in HCC remains unclear. We found numerous aslncRNAs were deregulated and might be involved in regulatory gene-net of HCC. The PCNA-AS1, antisense to PCNA, is significantly up-regulated in HCC and could promote tumor growth in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability. We concluded that asIncRNAs might act as upstream regulators in HCC and PCNA-AS1 could serve as a novel therapeutic target. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：87 / 94
页数：8
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