Highly Active [Pd(μ-Cl)(Cl)(NHC)]2 (NHC = N-Heterocyclic Carbene) in the Cross-Coupling of Grignard Reagents with Aryl Chlorides

被引：65
|
作者：
Hartmann, Caroline E. [1 ]
Nolan, Steven P. [1 ]
Cazin, Catherine S. J. [1 ]
机构：
[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain
来源：
ORGANOMETALLICS | 2009年 / 28卷 / 09期
关键词：
RESTRICTED FLEXIBILITY; PALLADIUM CATALYSTS; KUMADA REACTION; BR/MG EXCHANGE; BOND FORMATION; C-C; LIGANDS; COMPLEXES; ALCOHOLS; BROMIDES;
D O I：
10.1021/om900072f
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Cross-coupling reactions of Grignard reagents with functionalized aryl, heteroaryl, and sterically hindered aryl chlorides are reported. A protocol disclosing the coupling of a wide range of substrates using complexes of the type [Pd(mu-Cl)(Cl)(NHC)](2) (NHC = N-heterocyclic carbene) as precatalysts (at low catalyst loading) under mild conditions is presented. The system allows for the synthesis of highly sterically hindered products, including tri- and tetra-ortho-substituted biaryls.
引用
收藏
页码：2915 / 2919
页数：5
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