Highly Active [Pd(μ-Cl)(Cl)(NHC)]2 (NHC = N-Heterocyclic Carbene) in the Cross-Coupling of Grignard Reagents with Aryl Chlorides

被引：65

作者：

Hartmann, Caroline E. ^{[1
]}

Nolan, Steven P. ^{[1
]}

Cazin, Catherine S. J. ^{[1
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

来源：

ORGANOMETALLICS | 2009年 / 28卷 / 09期

关键词：

RESTRICTED FLEXIBILITY; PALLADIUM CATALYSTS; KUMADA REACTION; BR/MG EXCHANGE; BOND FORMATION; C-C; LIGANDS; COMPLEXES; ALCOHOLS; BROMIDES;

D O I：

10.1021/om900072f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cross-coupling reactions of Grignard reagents with functionalized aryl, heteroaryl, and sterically hindered aryl chlorides are reported. A protocol disclosing the coupling of a wide range of substrates using complexes of the type [Pd(mu-Cl)(Cl)(NHC)](2) (NHC = N-heterocyclic carbene) as precatalysts (at low catalyst loading) under mild conditions is presented. The system allows for the synthesis of highly sterically hindered products, including tri- and tetra-ortho-substituted biaryls.

引用

页码：2915 / 2919

页数：5

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