Biocompatibility of Ir/Ti-oxide coatings: Interaction with platelets, endothelial and smooth muscle cells

被引：8

作者：

Habibzadeh, Sajjad ^{[1
]}

Li, Ling ^{[2
]}

Omanovic, Sasha ^{[1
]}

Shum-Tim, Dominique ^{[3
,4
]}

Davis, Elaine C. ^{[2
]}

机构：

[1] McGill Univ, Dept Chem Engn, Montreal, PQ, Canada

[2] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ, Canada

[3] McGill Univ, Dept Surg, Div Cardiac Surg, Montreal, PQ H3A 2T5, Canada

[4] McGill Univ, Dept Surg, Div Surg Res, Montreal, PQ H3A 2T5, Canada

来源：

APPLIED SURFACE SCIENCE | 2014年 / 301卷

关键词：

Iridium/titanium-oxide coatings; Platelets; Endothelial cells; Smooth muscle cells; Biocompatibility; IMMERSION ION-IMPLANTATION; TITANIUM-NITRIDE-OXIDE; P-SELECTIN ANTAGONISM; DRUG-ELUTING STENTS; CORONARY-ARTERY; SURFACE-ROUGHNESS; STAINLESS-STEEL; LATE THROMBOSIS; COATED STENT; FILMS;

D O I：

10.1016/j.apsusc.2014.02.119

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Applying surface coatings on a biomedical implant is a promising modification technique which can enhance the implant's biocompatibility via controlling blood constituents- or/and cell-surface interaction. In this study, the influence of composition of IrxTi1-x-oxide coatings (x = 0, 0.2, 0.4, 0.6, 0.8, 1) formed on a titanium (Ti) substrate on the responses of platelets, endothelial cells (ECs) and smooth muscle cells (SMCs) was investigated. The results showed that a significant decrease in platelet adhesion and activation was obtained on Ir0.2Ti0.8-oxide and Ir0.4Ti0.6-oxide coatings, rendering the surfaces more blood compatible, in comparison to the control (316L stainless steel, 316L-SS) and other coating compositions. Further, a substantial increase in the EC/SMC surface count ratio after 4 h of cell attachment to the Ir0.2Ti0.8-oxide and Ir0.4Ti0.6-oxide coatings, relative to the 316L-SS control and the other coating compositions, indicated high potential of these coatings for the enhancement of surface endothelialization. This indicates the capability of the corresponding coating compositions to promote EC proliferation on the surface, while inhibiting that of SMCs, which is important in cardiovascular stents applications. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：530 / 538

页数：9

共 70 条

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