Synthesis, X-ray structure, electrochemical properties and cytotoxic effects of new arene ruthenium(II) complexes

被引：24

作者：

Pastuszko, Adam ^{[1
]}

Niewinna, Karolina ^{[2
]}

Czyz, Malgorzata ^{[2
]}

Jozwiak, Andrzej ^{[3
]}

Malecka, Magdalena ^{[4
]}

Budzisz, Elzbieta ^{[1
]}

机构：

[1] Med Univ Lodz, Fac Pharm, Dept Cosmet Raw Mat Chem, PL-90151 Lodz, Poland

[2] Med Univ Lodz, Dept Mol Biol Canc, PL-92215 Lodz, Poland

[3] Univ Lodz, Fac Chem, Dept Organ Chem, PL-91403 Lodz, Poland

[4] Univ Lodz, Dept Struct Chem & Crystallog, PL-90236 Lodz, Poland

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 745卷

关键词：

Synthesis; Arene ruthenium(II) complexes; X-ray structure; Cytotoxic effect; Cyclic voltammetry; MELANOMA-CELLS; PARTHENOLIDE; COORDINATION; ANTIOXIDANT; CHEMISTRY; CAPACITY; CANCER;

D O I：

10.1016/j.jorganchem.2013.07.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel half-sandwich organoruthenium(II) complexes with the general formula [(eta(6)-arene) Ru(L)Cl-2] (where L = flavone, chromone or benzofuranone derivatives) have been synthesized. All the ligands in the reaction with [(eta(6)-p-cymene)RuCl)(2)(mu-Cl)(2)] form monodentate compounds, which were fully characterized by elemental analysis, MS, UV-Vis, IR and NMR spectroscopy. The molecular structure of one of the complexes [(eta(6)-p-cymene)Ru(7-amino-3H-benzofuran-1-one-kappa(1)-N)Cl-2] was determined by X-ray crystallography. The redox properties of the complexes were monitored by cyclic voltammetry. The cytotoxicity of all obtained compounds has also been evaluated on several melanoma and leukemic cell lines. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：64 / 70

页数：7

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