Synthesis, X-ray structure, electrochemical properties and cytotoxic effects of new arene ruthenium(II) complexes

被引：24

作者：

Pastuszko, Adam ^{[1
]}

Niewinna, Karolina ^{[2
]}

Czyz, Malgorzata ^{[2
]}

Jozwiak, Andrzej ^{[3
]}

Malecka, Magdalena ^{[4
]}

Budzisz, Elzbieta ^{[1
]}

机构：

[1] Med Univ Lodz, Fac Pharm, Dept Cosmet Raw Mat Chem, PL-90151 Lodz, Poland

[2] Med Univ Lodz, Dept Mol Biol Canc, PL-92215 Lodz, Poland

[3] Univ Lodz, Fac Chem, Dept Organ Chem, PL-91403 Lodz, Poland

[4] Univ Lodz, Dept Struct Chem & Crystallog, PL-90236 Lodz, Poland

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 745卷

关键词：

Synthesis; Arene ruthenium(II) complexes; X-ray structure; Cytotoxic effect; Cyclic voltammetry; MELANOMA-CELLS; PARTHENOLIDE; COORDINATION; ANTIOXIDANT; CHEMISTRY; CAPACITY; CANCER;

D O I：

10.1016/j.jorganchem.2013.07.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel half-sandwich organoruthenium(II) complexes with the general formula [(eta(6)-arene) Ru(L)Cl-2] (where L = flavone, chromone or benzofuranone derivatives) have been synthesized. All the ligands in the reaction with [(eta(6)-p-cymene)RuCl)(2)(mu-Cl)(2)] form monodentate compounds, which were fully characterized by elemental analysis, MS, UV-Vis, IR and NMR spectroscopy. The molecular structure of one of the complexes [(eta(6)-p-cymene)Ru(7-amino-3H-benzofuran-1-one-kappa(1)-N)Cl-2] was determined by X-ray crystallography. The redox properties of the complexes were monitored by cyclic voltammetry. The cytotoxicity of all obtained compounds has also been evaluated on several melanoma and leukemic cell lines. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：64 / 70

页数：7

共 32 条

[1]

[Anonymous], T MED CHEM

[2] Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs [J].

Bergamo, Alberta ;

Sava, Gianni .

DALTON TRANSACTIONS, 2011, 40 (31) :7817-7823

[3]

Chen T., 2012, INORG CHEM, V49, P6366

[4] Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells [J].

Czyz, M. ;

Lesiak-Mieczkowska, K. ;

Koprowska, K. ;

Szulawska-Mroczek, A. ;

Wozniak, M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (05) :1144-1157

[5] Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres [J].

Czyz, Malgorzata ;

Koprowska, Kamila ;

Sztiller-Sikorska, Malgorzata .

CANCER BIOLOGY & THERAPY, 2013, 14 (02) :135-145

[6]

Di Braccio Mario, 2003, Farmaco (Lausanne), V58, P1083, DOI 10.1016/S0014-827X(03)00160-5

[7]

Frausin F, 2005, J PHARMACOL EXP THER, V313, P227, DOI 10.1124/jpet.104.078352

[8] Synthesis, structure, electrochemical properties, cytotoxic effects and antioxidant activity of 5-amino-8-methyl-4H-benzopyran-4-one and its copper(II) complexes [J].

Grazul, Magdalena ;

Kufelnicki, Aleksander ;

Wozniczka, Magdalena ;

Lorenz, Ingo-Peter ;

Mayer, Peter ;

Jozwiak, Andrzej ;

Czyz, Malgorzata ;

Budzisz, Elzbieta .

POLYHEDRON, 2012, 31 (01) :150-158

[9] Biological activity of metal ions complexes of chromones, coumarins and flavones [J].

Grazul, Magdalena ;

Budzisz, Elzbieta .

COORDINATION CHEMISTRY REVIEWS, 2009, 253 (21-22) :2588-2598

[10] KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients [J].

Hartinger, Christian G. ;

Jakupec, Michael A. ;

Zorbas-Seifried, Stefanie ;

Groessl, Michael ;

Egger, Alexander ;

Berger, Walter ;

Zorbas, Haralabos ;

Dyson, Paul J. ;

Keppler, Bernhard K. .

CHEMISTRY & BIODIVERSITY, 2008, 5 (10) :2140-2155

← 1 2 3 4 →