Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels

被引：116

作者：

Persson, Fredrik ^{[1
]}

Utko, Pawel ^{[1
]}

Reisner, Walter ^{[1
]}

Larsen, Niels B. ^{[1
]}

Kristensen, Anders ^{[1
]}

机构：

[1] Tech Univ Denmark, DTU Nanotech, Dept Micro & Nanotechnol, DK-2800 Kongens Lyngby, Denmark

来源：

NANO LETTERS | 2009年 / 9卷 / 04期

关键词：

FORCE; LENGTH;

D O I：

10.1021/nl803030e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.

引用

页码：1382 / 1385

页数：4

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