HEMOCIDINS DERIVED FROM HEMOGLOBIN: STRUCTURES, PROPERTIES AND PERSPECTIVES

被引：7

作者：

Carvalho, Larissa A. C. ^{[1
]}

Machini, Maria Teresa ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508900 Sao Paulo, Brazil

来源：

QUIMICA NOVA | 2013年 / 36卷 / 07期

关键词：

hemoglobin; antimicrobial peptides; microbial resistance; ANTIMICROBIAL PEPTIDES; BOVINE HEMOGLOBIN; ANTIBACTERIAL PEPTIDES; ANTIBIOTIC-RESISTANCE; BROAD-SPECTRUM; CELL-WALL; PROTEINS; MECHANISM; IMMUNITY; FRAGMENT;

D O I：

10.1590/S0100-40422013000700017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The increasing incidence of microbial infections, high toxicity, and high level of resistance associated with conventional antibiotics has created a need for new drugs. Antimicrobial peptides (AMPs) constitute a promising alternative and/or an important source of knowledge given their ability to inhibit the growth and/or to kill bacteria, fungi, parasites and/or viruses through mechanisms of action different from those of non-peptide drugs. This review focused on this important class of organic compounds that includes hemocidins resulting from hemoglobin proteolysis in vivo and in vitro or from chemical synthesis, subject of research in foreign and Brazilian laboratories.

引用

页码：1021 / 1029

页数：9

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