A droplet-based microfluidic system capable of droplet formation and manipulation

被引:22
作者
Lee, Chen-Yi [2 ]
Lin, Yen-Heng [3 ]
Lee, Gwo-Bin [1 ,2 ,3 ]
机构
[1] Med Elect & Device Technol Ctr, Ind Technol Res Inst, Hsinchu 310, Taiwan
[2] Natl Cheng Kung Univ, Inst Nanotechnol & Microsyst Engn, Tainan 701, Taiwan
[3] Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan
关键词
Emulsification; Moving wall; Flow focusing; Microfluidics; MEMS; MEMBRANE EMULSIFICATION; MONODISPERSE DROPLETS; FLOW SWITCHES; GENERATION; EMULSIONS; BREAKUP;
D O I
10.1007/s10404-008-0340-2
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Formation of emulsion droplets is crucial for a variety of industrial and scientific applications. This study presents a new droplet-based microfluidic system capable of generating tunable and uniform-sized droplets and subsequently deflecting these droplets at various inclination angles using a combination of flow-focusing and moving-wall structures. A pneumatic air chamber was used to activate the moving-wall structures, located nearby the outlet of the flow-focusing microchannels, such that the sheath flows can be locally accelerated. With this approach, the size of the droplets can be fine-tuned and sorted without adjusting the syringe pumps. Experimental data showed that droplets with diameters ranging from 31.4 to 146.2 mu m with a variation of less than 5.39% can be generated. Besides, droplets can be sorted upwards or backwards with an inclination angle ranging from 0A degrees to 53.5A degrees. The development of this emulsion system may be promising for the formation and collection of emulsion products for applications in the pharmaceutical, cosmetics and food industries.
引用
收藏
页码:599 / 610
页数:12
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