Sagittal abdominal diameter resembles waist circumference as a surrogate marker of insulin resistance in adolescents-Brazilian Metabolic Syndrome Study

被引:8
作者
da Silva, Cleliani de Cassia [1 ,2 ]
Vasques, Ana Carolina J. [1 ,2 ,3 ]
Zambon, Mariana P. [2 ,4 ]
Camilo, Daniella F. [1 ,2 ]
De Bernardi Rodrigues, Ana Maria [1 ,5 ]
Antonio, Maria Angela R. G. M. [2 ,4 ]
Geloneze, Bruno [1 ,2 ,6 ]
机构
[1] Univ Campinas Unicamp, Lab Invest Metab & Diabet Limed, Gastroenterol Diag & Res Ctr Gastroctr, 420 Carlos Chagas St, BR-13081970 Campinas, SP, Brazil
[2] Univ Campinas Unicamp, Fac Med Sci, Postgrad Program Child & Adolescent Hlth, Campinas, SP, Brazil
[3] Univ Campinas Unicamp, Sch Appl Sci, Limeira, SP, Brazil
[4] Univ Campinas Unicamp, Dept Pediat, Campinas, SP, Brazil
[5] Univ Ctr Our Lady Patronage, Sch Hlth & Life Sci, Itu, SP, Brazil
[6] Natl Inst Sci & Technol Obes & Diabet, Campinas, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
abdominal obesity; adolescents; glucose clamp technique; insulin resistance; sagittal abdominal diameter; BETA-CELL FUNCTION; VISCERAL ADIPOSE-TISSUE; SELF-ASSESSMENT; CHILDREN; SENSITIVITY; PREDICTOR; CLAMP; FAT; MATURATION; SECRETION;
D O I
10.1111/pedi.12664
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate the association of the sagittal abdominal diameter (SAD) with insulin resistance (IR) and metabolic syndrome (MetS) components, and to compare SAD with waist circumference (WC). Subjects/Methods: This was a multicenter, cross-sectional study of 520 adolescents (10- to 18-years old). IR was assessed using the homeostasis model assessment of IR (HOMA-IR) and the hyperglycaemic clamp (n=76). Results: SAD and WC were positively correlated with HOMA-IR (r=0.637 and r=0.653) and inversely correlated with the clamp-derived insulin sensitivity index (ISI) (r=-0.734 and r=-0.731); P<.001. In the multivariable linear regression analysis, SAD was positively associated with HOMA-IR (B=0.046 +/- 0.003) and inversely associated with the clamp-derived ISI (B=-0.084 +/- 0.009) after adjusting for sex, age, and Tanner's stages (P<.001). When WC replaced the SAD, it was positively associated with HOMA-IR (B=0.011 +/- 0.001) and inversely associated with the clamp-derived ISI (B=-0.018 +/- 0.002); P<.001. The values of the areas under the curves (AUC) were 0.823 and 0.813 for SAD and WC, respectively. In Bland-Altman analysis, there were agreement between both, SAD and WC, with the clamp-derived ISI (mean=0.00; P>.05). The SAD and WC were positively associated with blood pressure, triglycerides, and uric acid, and inversely associated with high-density lipoprotein (HDL)-cholesterol after adjusting for sex, age, and Tanner's stages. Conclusion: The SAD was associated with IR and MetS components, with a good discriminatory power for detecting IR. When compared to WC, SAD showed equivalent results.
引用
收藏
页码:882 / 891
页数:10
相关论文
共 41 条
[1]   Association of body mass index, sagittal abdominal diameter and waist-hip ratio with cardiometabolic risk factors and adipocytokines in Arab children and adolescents [J].
Al-Attas, Omar S. ;
Al-Daghri, Nasser M. ;
Alokail, Majed S. ;
Alkharfy, Khalid M. ;
Draz, Hossam ;
Yakout, Sobhy ;
Sabico, Shaun ;
Chrousos, George .
BMC PEDIATRICS, 2012, 12
[2]  
[Anonymous], 2002, HEALTH-LONDON
[3]  
[Anonymous], 2008, WHO STEP WIS APPR SU
[4]   Clamp techniques in paediatrics: What have we learned? [J].
Arslanian, SA .
HORMONE RESEARCH, 2005, 64 :16-24
[5]   Longitudinal changes in insulin sensitivity, insulin secretion, and β-cell function during puberty [J].
Ball, GDC ;
Huang, TTK ;
Gower, BA ;
Cruz, ML ;
Shaibi, GQ ;
Weigensberg, MJ ;
Goran, MI .
JOURNAL OF PEDIATRICS, 2006, 148 (01) :16-22
[6]   Hypertriglyceridemic Waist Phenotype Indicates Insulin Resistance in Adolescents According to the Clamp Technique in the BRAMS Study [J].
Barreiro-Ribeiro, Francieli ;
Junqueira Vasques, Ana Carolina ;
da Silva, Cleliani de Cassia ;
Zambon, Mariana Porto ;
De Bernardi Rodrigues, Ana Maria ;
Camilo, Daniella Fernandes ;
de Goes Monteiro Antonio, Maria Angela Reis ;
Damaso, Ana Raimunda ;
da Silveira Campos, Raquel Munhoz ;
Tufik, Sergio ;
de Mello, Marco Tulio ;
Geloneze, Bruno .
CHILDHOOD OBESITY, 2016, 12 (06) :446-454
[7]   Type 2 Diabetes in Youth: Epidemiology and Pathophysiology [J].
D'Adamo, Ebe ;
Caprio, Sonia .
DIABETES CARE, 2011, 34 :S161-S165
[8]   Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009 [J].
Dabelea, Dana ;
Mayer-Davis, Elizabeth J. ;
Saydah, Sharon ;
Imperatore, Giuseppina ;
Linder, Barbara ;
Divers, Jasmin ;
Bell, Ronny ;
Badaru, Angela ;
Talton, Jennifer W. ;
Crume, Tessa ;
Liese, Angela D. ;
Merchant, Anwar T. ;
Lawrence, Jean M. ;
Reynolds, Kristi ;
Dolan, Lawrence ;
Liu, Lenna L. ;
Hamman, Richard F. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 311 (17) :1778-1786
[9]  
DUKE PM, 1980, PEDIATRICS, V66, P918
[10]  
Ewald D Rose, 2016, Glob Pediatr Health, V3, p2333794X15625159, DOI 10.1177/2333794X15625159