S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice

被引：13

作者：

Hooijmans, Carlijn R. ^{[1
,2
]}

Blom, Henk J. ^{[3
]}

Oppenraaij-Emmerzaal, Dinny ^{[3
]}

Ritskes-Hoitinga, Merel ^{[4
]}

Kiliaan, Amanda J. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Anat, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Ctr Neurosci, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Lab Pediat & Neurol, NL-6500 HB Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Cent Anim Lab, NL-6500 HB Nijmegen, Netherlands

来源：

NEUROLOGICAL SCIENCES | 2009年 / 30卷 / 05期

关键词：

S-adenosylmethionine; S-adenosylhomocysteine; Alzheimer's disease; APP/PS1; mice; Cholesterol; DHA; RANDOMIZED-TRIALS; AMYLOID PATHOLOGY; VASCULAR-DISEASE; DOUBLE-BLIND; FOLIC-ACID; HOMOCYSTEINE; SUPPLEMENTATION; CHOLESTEROL; CYCLE; HYPERCHOLESTEROLEMIA;

D O I：

10.1007/s10072-009-0110-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hyperhomocysteinemia and factors of homocysteine metabolism, S-adenosylhomocysteine (AdoHcy) and S-adenosylmethionine (AdoMet), may play a role in Alzheimer's disease (AD). With liquid-chromatography-tandem-mass-spectrometry AdoMet and AdoHcy were determined in brains of 8- and 15-month-old APP/PS1 Alzheimer mice, and their possible roles in AD brains investigated. The finding that AdoMet levels do not differ between the genotypes in (young) 8-month-old mice, but are different in (older) 15-month-old APP/PS1 mice compared to their wild-type littermates, suggests that alterations in AdoMet are a consequence of AD pathology rather than a cause. During aging, AdoMet levels decreased in the brains of wild-type mice, whereas AdoHcy levels diminished in both wild type and APP/PS1 mice. The finding that AdoMet levels in APP/PS1 mice are not decreased during aging (in contrast to wild-type mice), is probably related to less demand due to neurodegeneration. No effect of the omega-3 fatty acid docosahexaenoic acid (DHA) or cholesterol-enriched diets on AdoMet or AdoHcy levels were found.

引用

页码：439 / 445

页数：7

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