1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity

被引：3

作者：

Dhouafli, Zohra ^{[1
,2
]}

Leri, Manuela ^{[3
,4
]}

Bucciantini, Monica ^{[3
]}

Stefani, Massimo ^{[3
,4
]}

Gadhoumi, Hamza ^{[1
,2
]}

Mahjoub, Borhane ^{[5
]}

Ben Jannet, Hichem ^{[6
]}

Guillard, Jerome ^{[7
]}

Ksouri, Riadh ^{[2
]}

Tounsi, Moufida Saidani ^{[2
]}

Soto, Claudio ^{[8
]}

Hayouni, El Akrem ^{[2
]}

机构：

[1] Univ Tunis El Manar, Fac Sci Tunis, Tunis 2092, Tunisia

[2] Ctr Biotechnol Borj Cedria, Lab Plantes Aromat & Med LPAM LR15CBB, Hammam Lif, Tunisia

[3] Univ Florence, Dept Biomed Expt & Clin Sci Mario Serio, Florence, Italy

[4] Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

[5] Inst Super Agron Chott Meriem, Lab Chim, Sousse, Tunisia

[6] Univ Monastir, Fac Sci Monastir, Equipe Chim Med & Prod Nat, Lab Chim Heterocycl Prod Nat & React LR11ES39, Monastir, Tunisia

[7] CNRS, Inst Chim Milieux & Mat Poitiers, UMR 7285, Poitiers 9, France

[8] Univ Texas Med Sch Houston, Mitchell Ctr Alzheimers Dis & Related Brain Disor, Houston, TX USA

来源：

BIOFACTORS | 2018年 / 44卷 / 03期

关键词：

amyloid cytotoxicity; natural polyphenols; Alzheimer's disease; THNG; A beta 42 aggregation; ALZHEIMERS-DISEASE; IN-VITRO; BETA; FIBRILS; PEPTIDE; PATHOGENESIS; MECHANISM; TOXICITY; BINDING; BRAIN;

D O I：

10.1002/biof.1422

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Presently, misfolding and aggregation of amyloid-(42) (A(42)) are considered early events in Alzheimer's disease (AD) pathogenesis. The use of natural products to inhibit the aggregation process and to protect cells from cytotoxicity of early aggregate grown at the onset of the aggregation path is one of the promising strategies against AD. Recently, we have purified a new powerful antioxidant and inhibitor of A(42) aggregation from the leaves of Lawsonia inermis. The new compound was identified as a new Lawsoniaside; 1,2,4-trihydroxynaphthalene-2-O--D-glucopyranoside (THNG). Herein, we show that THNG interferes with A(42) aggregation, inhibits its conformational change to a -sheet-rich structure, decreases its polymerization into large fibrillar species, reduces oxidative stress, and aggregate cytotoxicity. These results indicate that THNG has great potential as a neuroprotective and therapeutic agent against AD. (c) 2018 BioFactors, 44(3):272-280, 2018

引用

页码：272 / 280

页数：9

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