Catalysis of the Biginelli reaction by NiCl2•6H2O -: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

被引：0

作者：

Lu, J ^{[1
]}

Wang, FL

Bai, YJ

Li, WH

机构：

[1] NW Univ Xian, Dept Chem, Xian 710069, Peoples R China

[2] NW Univ Xian, Dept Chem Engn, Xian 710069, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 22卷 / 10期

关键词：

Biginelli reaction; nickel chloride hexahydrate; 3,4-dihydropyrimidine-2 (1H)-one; one-pot process;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidinones from aldehyde, beta-keto ester and urea in ethanol, where nickel chloride hexahydrate was used as a catalyst, is described. The modified Biginelli's one-pot cyclocondensation not only shortens the reaction period and simplifies the operation, but also improves the yields.

引用

页码：788 / 792

页数：5

共 25 条

[1]

Christoffers J, 2000, EUR J ORG CHEM, V2000, P701, DOI 10.1002/(SICI)1099-0690(200003)2000:5<701::AID-EJOC701>3.0.CO

[2]

2-5

[3] Researches on pyrimidines CXXXIV The reaction of phenylacetaldehyde and acetophenone with urea [J].