Studies on the synthesis of trisaccharide analogues of the antibiotic moenomycin A

被引：9

作者：

Yang, GB ^{[1
]}

Hennig, L ^{[1
]}

Findeisen, M ^{[1
]}

Oehme, R ^{[1
]}

Giesa, S ^{[1
]}

Welzel, P ^{[1
]}

机构：

[1] Univ Leipzig, Fak Chem & Mineral, D-04103 Leipzig, Germany

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 07期

关键词：

D O I：

10.1002/hlca.200490160

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach for the synthesis of moenomycin trisaccharide analogues is reported in which three monosaccharide building blocks are used and allows the introduction of different substituents at the 6-position of unit E (Scheme 2). Furthermore, a new procedure for the introduction and manipulation of unit F is described (Scheme 3).

引用

页码：1794 / 1806

页数：13

共 45 条

[1] Anikin A, 1999, ANGEW CHEM INT EDIT, V38, P3703, DOI 10.1002/(SICI)1521-3773(19991216)38:24<3703::AID-ANIE3703>3.0.CO
[2] 2-1
[3] ANIKIN A, 1999, ANGEW CHEM, V111, P3931
[4] Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase
Baizman, ER
Branstrom, AA
Longley, CB
Allanson, N
Sofia, MJ
Gange, D
Goldman, RC
[J]. MICROBIOLOGY-SGM, 2000, 146 : 3129 - 3140
[5] THE CHEMISTRY OF CYCLIC VINYL ETHERS .6. TOTAL SYNTHESIS OF POLYETHER IONOPHORE ANTIBIOTICS OF THE CALCIMYCIN (A-23187) CLASS
BOECKMAN, RK
CHARETTE, AB
ASBEROM, T
JOHNSTON, BH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (14) : 5337 - 5353
[6] NEW SYNTHETIC TRICKS - TRIMETHYLSILYL TRIFLATE MEDIATED CLEAVAGE OF HINDERED SILYL ETHERS
BOU, V
VILARRASA, J
[J]. TETRAHEDRON LETTERS, 1990, 31 (04) : 567 - 568
[7] In situ assay for identifying inhibitors of bacterial transglycosylase
Branstrom, AA
Midha, S
Goldman, RC
[J]. FEMS MICROBIOLOGY LETTERS, 2000, 191 (02) : 187 - 190
[8] Synthesis of tools for raising antibodies against moenomycin epitopes and initial immunological studies
Buchynskyy, A
Stembera, K
Knoll, D
Vogel, S
Kempin, U
Biallass, A
Henning, L
Findeisen, M
Müller, D
Welzel, P
[J]. TETRAHEDRON, 2002, 58 (38) : 7741 - 7760
[9] Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate
Chen, L
Walker, D
Sun, B
Hu, Y
Walker, S
Kahne, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) : 5658 - 5663
[10] COPELAND RA, 1996, ENZYMES PRACTICAL IN, P225

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