Long Non-coding RNAs in Gammaherpesvirus Infections: Their Roles in Tumorigenic Mechanisms

被引：7

作者：

Liu, Wen ^{[1
]}

Zhang, Yan ^{[1
,2
]}

Luo, Bing ^{[1
]}

机构：

[1] Qingdao Univ, Sch Basic Med, Dept Pathogen Biol, Qingdao, Peoples R China

[2] Zibo Cent Hosp, Dept Clin Lab, Zibo, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 11卷

基金：

中国博士后科学基金;

关键词：

gammaherpesvirus; Epstein-Barr virus; KSHV; lncRNA; tumorigenesis; EPSTEIN-BARR-VIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; POLYADENYLATED NUCLEAR-RNA; GASTRIC-CANCER CELLS; NASOPHARYNGEAL CARCINOMA PROGRESSION; CLINICOPATHOLOGICAL FEATURES; CISPLATIN RESISTANCE; MOLECULAR-MECHANISMS; SIGNALING PATHWAYS; GENE-EXPRESSION;

D O I：

10.3389/fmicb.2020.604536

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Long non-coding RNAs (lncRNAs) regulate gene expression at the epigenetic, transcriptional, or posttranscriptional level by interacting with protein, DNA, and RNA. Emerging evidence suggests that various lncRNAs are abnormally expressed and play indispensable roles in virus-triggered cancers. Besides, a growing number of studies have shown that virus-encoded lncRNAs participate in tumorigenesis. However, the functions of most lncRNAs in tumors caused by oncogenic viruses and their underlying mechanisms remain largely unknown. In this review, we summarize current findings regarding lncRNAs involved in cancers caused by Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV). Additionally, we discuss the contribution of lncRNAs to tumor occurrence, development, invasion, and metastasis; the roles of lncRNAs in key signaling pathways and their potential as biomarkers and therapeutic targets for tumor diagnostics and treatment.

引用

页数：13

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