MYC in Regulating Immunity: Metabolism and Beyond

被引：78
作者：
Gnanaprakasam, J. N. Rashida [1 ]
Wang, Ruoning [1 ]
机构：
[1] Ohio State Univ, Nationwide Childrens Hosp, Res Inst, Ctr Childhood Canc & Blood Dis,Hematol Oncol & BM, Columbus, OH 43205 USA
来源：
GENES | 2017年 / 8卷 / 03期
关键词：
MYC; immunity; metabolism; T-CELL-ACTIVATION; C-MYC; DENDRITIC CELLS; TRANSCRIPTION FACTOR; GLUCOSE-METABOLISM; ANTIGEN-RECEPTOR; ALTERNATIVE ACTIVATION; GLUTAMINE-METABOLISM; LINEAGE COMMITMENT; MACROPHAGE HETEROGENEITY;
D O I：
10.3390/genes8030088
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derived MYC (MYCN), and lung carcinoma derived MYC (MYCL), have all been implicated as key oncogenic drivers in a broad range of human cancers. Beyond cancer, MYC plays an important role in other physiological and pathological processes, namely immunity and immunological diseases. MYC largely functions as a transcription factor that promotes the expression of numerous target genes to coordinate death, proliferation, and metabolism at the cellular, tissue, and organismal levels. It has been shown that the expression of MYC family members is tightly regulated in immune cells during development or upon immune stimulations. Emerging evidence suggests that MYC family members play essential roles in regulating the development, differentiation and activation of immune cells. Through driving the expression of a broad range of metabolic genes in immune cells, MYC family members coordinate metabolic programs to support immune functions. Here, we discuss our understanding of MYC biology in immune system and how modulation of MYC impacts immune metabolism and responses.
引用
收藏
页数：15
相关论文
共 143 条
[1]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[2]   THE C-MYC PROTEIN INDUCES CELL-CYCLE PROGRESSION AND APOPTOSIS THROUGH DIMERIZATION WITH MAX [J].
AMATI, B ;
LITTLEWOOD, TD ;
EVAN, GI ;
LAND, H .
EMBO JOURNAL, 1993, 12 (13) :5083-5087
[3]   ONCOGENIC ACTIVITY OF THE C-MYC PROTEIN REQUIRES DIMERIZATION WITH MAX [J].
AMATI, B ;
BROOKS, MW ;
LEVY, N ;
LITTLEWOOD, TD ;
EVAN, GI ;
LAND, H .
CELL, 1993, 72 (02) :233-245
[4]  
[Anonymous], PERSPECT MED
[5]   Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells [J].
Auffray, Cedric ;
Sieweke, Michael H. ;
Geissmann, Frederic .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :669-692
[6]   Immunobiology of dendritic cells [J].
Banchereau, J ;
Briere, F ;
Caux, C ;
Davoust, J ;
Lebecque, S ;
Liu, YT ;
Pulendran, B ;
Palucka, K .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+
[7]   Dendritic cells and the control of immunity [J].
Banchereau, J ;
Steinman, RM .
NATURE, 1998, 392 (6673) :245-252
[8]   Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors [J].
Bandukwala, Hozefa S. ;
Gagnon, John ;
Togher, Susan ;
Greenbaum, Jason A. ;
Lamperti, Edward D. ;
Parr, Nigel J. ;
Molesworth, Amy M. H. ;
Smithers, Nicholas ;
Lee, Kevin ;
Witherington, Jason ;
Tough, David F. ;
Prinjha, Rab K. ;
Peters, Bjoern ;
Rao, Anjana .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (36) :14532-14537
[9]   c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression [J].
Baudino, TA ;
McKay, C ;
Pendeville-Samain, H ;
Nilsson, JA ;
Maclean, KH ;
White, EL ;
Davis, AC ;
Ihle, JN ;
Cleveland, JL .
GENES & DEVELOPMENT, 2002, 16 (19) :2530-2543
[10]   IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors [J].
Becker, Amy M. ;
Michael, Drew G. ;
Satpathy, Ansuman T. ;
Sciammas, Roger ;
Singh, Harinder ;
Bhattacharya, Deepta .
BLOOD, 2012, 119 (09) :2003-2012
12345678910