Differential expression patterns of the basic Helix-Loop-Helix transcription factors during aging of the murine brain

被引：21
作者：
Uittenbogaard, M
Chiaramello, A
机构：
[1] George Washington Univ, Med Ctr, Dept Anat & Cell Biol, Washington, DC 20037 USA
[2] George Washington Univ, Med Ctr, Program Neurosci, Washington, DC 20037 USA
[3] George Washington Univ, Med Ctr, Grad Program Genet, Washington, DC 20037 USA
来源：
NEUROSCIENCE LETTERS | 2000年 / 280卷 / 02期
基金：
美国国家科学基金会;
关键词：
basic Helix-Loop-Helix transcription factors; E-proteins; tcf-4; gene; ME2; NeuroD; cerebellum; hippocampus;
D O I：
10.1016/S0304-3940(00)00761-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we investigated the expression pattern of the basic Helix-Loop-Helix transcription factors during brain aging. We provide the first evidence that NeuroD and ME2 are differentially expressed during brain aging. Modulation of their expression is specific to distinct areas of the aging brain. NeuroD expression is sustained at high levels in aging cerebellum, whereas it severely declines in aging hippocampus. In contrast, the bHLH E-protein ME2 remains expressed in both aged cerebellum and hippocampus, although at lower levels. These observations support the idea that a shift in the transcriptional dynamics controlling gene expression is associated with the progressive functional decline observed during brain aging. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：95 / 98
页数：4
相关论文
共 19 条
  • [1] Cellular and molecular biology of neural crest cell lineage determination
    Anderson, DJ
    [J]. TRENDS IN GENETICS, 1997, 13 (07) : 276 - 280
  • [2] BICKFORD P, 1995, REV NEUROSCIENCE, V6, P35
  • [3] BINDING OF MYC PROTEINS TO CANONICAL AND NONCANONICAL DNA-SEQUENCES
    BLACKWELL, TK
    HUANG, J
    MA, A
    KRETZNER, L
    ALT, FW
    EISENMAN, RN
    WEINTRAUB, H
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (09) : 5216 - 5224
  • [4] EXPERIMENTAL APPROACHES TO AGE-RELATED COGNITIVE IMPAIRMENTS
    GAGE, FH
    CHEN, KS
    BUZSAKI, G
    ARMSTRONG, D
    [J]. NEUROBIOLOGY OF AGING, 1988, 9 (5-6) : 645 - 655
  • [5] Basic helix-loop-helix genes in neural development
    Lee, JE
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (01) : 13 - 20
  • [6] CONVERSION OF XENOPUS ECTODERM INTO NEURONS BY NEUROD, A BASIC HELIX-LOOP-HELIX PROTEIN
    LEE, JE
    HOLLENBERG, SM
    SNIDER, L
    TURNER, DL
    LIPNICK, N
    WEINTRAUB, H
    [J]. SCIENCE, 1995, 268 (5212) : 836 - 844
  • [7] NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia
    Ma, QF
    Fode, C
    Guillemot, F
    Anderson, DJ
    [J]. GENES & DEVELOPMENT, 1999, 13 (13) : 1717 - 1728
  • [8] Structure and regulation of the human NeuroD (BETA2/BHF1) gene
    Miyachi, T
    Maruyama, H
    Kitamura, T
    Nakamura, S
    Kawakami, H
    [J]. MOLECULAR BRAIN RESEARCH, 1999, 69 (02): : 223 - 231
  • [9] NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus
    Miyata, T
    Maeda, T
    Lee, JE
    [J]. GENES & DEVELOPMENT, 1999, 13 (13) : 1647 - 1652
  • [10] Life and death of neurons in the aging brain
    Morrison, JH
    Hof, PR
    [J]. SCIENCE, 1997, 278 (5337) : 412 - 419
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