Differential expression patterns of the basic Helix-Loop-Helix transcription factors during aging of the murine brain

被引：21
|
作者：
Uittenbogaard, M
Chiaramello, A
机构：
[1] George Washington Univ, Med Ctr, Dept Anat & Cell Biol, Washington, DC 20037 USA
[2] George Washington Univ, Med Ctr, Program Neurosci, Washington, DC 20037 USA
[3] George Washington Univ, Med Ctr, Grad Program Genet, Washington, DC 20037 USA
来源：
NEUROSCIENCE LETTERS | 2000年 / 280卷 / 02期
基金：
美国国家科学基金会;
关键词：
basic Helix-Loop-Helix transcription factors; E-proteins; tcf-4; gene; ME2; NeuroD; cerebellum; hippocampus;
D O I：
10.1016/S0304-3940(00)00761-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we investigated the expression pattern of the basic Helix-Loop-Helix transcription factors during brain aging. We provide the first evidence that NeuroD and ME2 are differentially expressed during brain aging. Modulation of their expression is specific to distinct areas of the aging brain. NeuroD expression is sustained at high levels in aging cerebellum, whereas it severely declines in aging hippocampus. In contrast, the bHLH E-protein ME2 remains expressed in both aged cerebellum and hippocampus, although at lower levels. These observations support the idea that a shift in the transcriptional dynamics controlling gene expression is associated with the progressive functional decline observed during brain aging. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：95 / 98
页数：4
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