Antitumor activity of dextran derivatives immobilizing platinum complex (II)

被引：39

作者：

Ichinose, K

Tomiyama, N

Nakashima, M

Ohya, Y

Ichikawa, M

Ouchi, T

Kanematsu, T

机构：

[1] Nagasaki Univ, Sch Med, Dept Surg 2, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Sch Med, Dept Hosp Pharm, Nagasaki 8528501, Japan

[3] Kansai Univ, Fac Engn, Dept Appl Chem, Osaka 5640073, Japan

来源：

ANTI-CANCER DRUGS | 2000年 / 11卷 / 01期

关键词：

antitumor activity; cisplatin; dextran; drug delivery system; polymeric drug;

D O I：

10.1097/00001813-200001000-00006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The in vivo antitumor activity and toxicity of a newly synthesized polymeric prodrug of cisplatin was investigated and also compared with plain cisplatin. The prodrug included a dicarboxymethyl-dextran conjugate of cisplatin (DCM-Dex/CDDP). DCM-Dex/CDDP was i.v. injected in mice bearing s.c. Colon 26 mouse colon cancer cells. The tissue distribution of platinum was thereafter determined by flameless atomic absorption spectrophotometry. The platinic concentration of the organs showed a high rate of retention at 24 h after injection in the DCM-Dex/CDDP-treated mice. No biochemical or hematologically adverse effects were observed. In addition, DCM-Dex/CDDP showed a significantly higher antitumor activity than cisplatin alone. These results indicate that DCM-Dex/CDDP may therefore be a potentially effective cancer chemotherapy. [(C) 2000 Lippincott Williams & Wilkins.].

引用

页码：33 / 38

页数：6