Regioselective entry to bromo-γ-hydroxybutenolides:: Useful building blocks for assemblying natural product-like libraries

被引：35

作者：

Aquino, M. ^{[1
]}

Bruno, I. ^{[1
]}

Riccio, R. ^{[1
]}

Gomez-Paloma, L. ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 21期

关键词：

D O I：

10.1021/ol0618611

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a regioselective entry to 3-bromo- and 4-bromo-5-hydroxy-5H-furan-2-ones by photooxidation of 3-bromofuran with a singlet oxygen in the presence of a suitable base. By this procedure, a variety of 3-substituted gamma-hydroxybutenolides have become for the first time easily accessible. Strategies employing these highly functionalized building blocks for the preparation of focused libraries of natural-like molecules are also discussed.

引用

页码：4831 / 4834

页数：4

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