Enantioselective synthesis of polyketide segments through vinylogous Mukaiyama aldol reactions

被引：28
作者：
Simsek, Serkan [1 ]
Kalesse, Markus [1 ]
机构：
[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期
关键词：
Vinylogous Mukaiyama aldol; Polyketides; Oxazaborolidines; Natural products; Enantioselective; STEREOCONTROLLED TOTAL-SYNTHESIS; LEWIS-BASE ACTIVATION; NATURAL-PRODUCTS; ACIDS; ROFLAMYCOIN; ADDITIONS; CATALYST; COMPLEX;
D O I：
10.1016/j.tetlet.2009.03.013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of polyketide segments through the vinylogous Mukaiyama aldol reaction is reported. The use of chiral oxazaborolidines allows using terminal substituted ketene acetals and provides access to extended segments and two new chiral centers. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3485 / 3488
页数：4
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