Cell and tissue engineering for liver disease

被引：221
作者：
Bhatia, Sangeeta N. [1 ,2 ,3 ]
Underhill, Gregory H. [4 ]
Zaret, Kenneth S. [5 ]
Fox, Ira J. [6 ,7 ]
机构：
[1] MIT, Dept Elect Engn & Comp Sci, David H Koch Inst, Inst Med Engn & Sci, Cambridge, MA 02139 USA
[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[3] Brigham & Womens Hosp, Div Med, Boston, MA 02115 USA
[4] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA
[5] Univ Penn, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA
[6] Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh UPMC, Dept Surg, Pittsburgh, PA 15224 USA
[7] McGowan Inst Regenerat Med, Pittsburgh, PA 15224 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 245期
关键词：
HEPATITIS-C VIRUS; EMBRYONIC STEM-CELLS; HEPATOCYTE-LIKE CELLS; ADULT-RAT HEPATOCYTES; SINUSOIDAL ENDOTHELIAL-CELLS; BILIARY EPITHELIAL-CELLS; IN-VITRO; BIOARTIFICIAL LIVER; EXTRACELLULAR-MATRIX; HEPATOCELLULAR TRANSPLANTATION;
D O I：
10.1126/scitranslmed.3005975
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.
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页数：21
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