Human bone marrow endothelial cells:: a new identified source of B-type natriuretic peptide

被引:9
作者
Bordenave, L [1 ]
Georges, A [1 ]
Bareille, R [1 ]
Conrad, V [1 ]
Villars, F [1 ]
Amédée, J [1 ]
机构
[1] Univ Victor Segalen Bordeaux 2, INSERM, U443, F-33076 Bordeaux, France
关键词
endothelium; B-type natriuretic peptide; cell culture;
D O I
10.1016/S0196-9781(02)00004-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
B-type natriuretic peptide (BNP) is a hormone mainly secreted by cardiac ventricle myocytes and which is increased in cardiac diseases. Moreover, BNP expression has been shown in various cell/tissue types. Six different human endothelial cell (EC) culture models arising from macro and microcirculation either primary cultures or cell lines were cultured and screened for BNP presence and secretion. All cell types expressed BNP mRNA while only the ECs arising from bone marrow stromal compartment secreted high amounts of BNP protein. This report is the first to identify ECs as a new source of BNP. However, BNP secretion is limited to a particular EC type. (C) 2002 Published by Elsevier Science Inc.
引用
收藏
页码:935 / 940
页数:6
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