Gut microbiota and obesity: Role in aetiology and potential therapeutic target

被引：83

作者：

Moran, Carthage P. ^{[1
]}

Shanahan, Fergus ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Dept Med & Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2014年 / 28卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

Microbiota; Obesity; Endocannabinoids; Bile acids; DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS; SALT HYDROLASE ACTIVITY; BILE-ACID; INTESTINAL MICROBIOTA; WEIGHT-LOSS; METAGENOMIC ANALYSIS; NUTRIENT ABSORPTION; ENERGY-BALANCE; MICE;

D O I：

10.1016/j.bpg.2014.07.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Obesity is epidemic; chronic energy surplus is clearly important in obesity development but other factors are at play. Indigenous gut microbiota are implicated in the aetiopathogenesis of obesity and obesity-related disorders. Evidence from murine models initially suggested a role for the gut microbiota in weight regulation and the microbiota has been shown to contribute to the low grade inflammation that characterises obesity. The microbiota and its metabolites mediate some of the alterations of the microbiota-gut-brain axis, the endocannabinoid system, and bile acid metabolism, found in obesity-related disorders. Modulation of the gut microbiota is an attractive proposition for prevention or treatment of obesity, particularly as traditional measures have been suboptimal (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：585 / 597

页数：13

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