Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss

被引：90

作者：

Colleluori, Georgia ^{[1
,2
,11
]}

Aguirre, Lina ^{[3
,4
]}

Phadnis, Uma ^{[1
,2
]}

Fowler, Kenneth ^{[3
,4
]}

Armamento-Villarea, Reina ^{[1
,2
]}

Sun, Zheng ^{[1
]}

Brunetti, Lorenzo ^{[5
]}

Park, Jun Hyoung ^{[6
]}

Kaipparettu, Benny Abraham ^{[6
]}

Putluri, Nagireddy ^{[6
,7
]}

Auetumrongsawat, Vimlin ^{[1
,2
]}

Yarasheski, Kevin ^{[8
]}

Qualls, Clifford ^{[9
,10
]}

Villarea, Dennis T. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Div Endocrinol Diabet & Metab, Houston, TX 77030 USA

[2] Michael E DeBakey VA Med Ctr, CTRID, Houston, TX 77030 USA

[3] Univ New Mexico, Sch Med, New Mexico VA Hlth Care Syst, Med Care Line, Albuquerque, NM 87108 USA

[4] Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87108 USA

[5] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[7] Baylor Coll Med, Adv Technol Core, Houston, TX 77030 USA

[8] Washington Univ, Sch Med, Dept Internal Med, Div Metab Endocrinol & Diabet, St Louis, MO 63110 USA

[9] Univ New Mexico, Dept Math & Stat, Sch Med, Albuquerque, NM 87108 USA

[10] Univ New Mexico, Sch Med, Albuquerque, NM 87108 USA

[11] Univ Politecn Marche, Dept Clin & Expt Med, Via Tronto 10A, I-60020 Ancona, Italy

来源：

CELL METABOLISM | 2019年 / 30卷 / 02期

关键词：

FRACTIONAL SYNTHESIS RATE; TERMINAL AGRIN FRAGMENT; SKELETAL-MUSCLE; CALORIC RESTRICTION; INSULIN SENSITIVITY; ANABOLIC RESPONSE; ELDERLY-MEN; FED STATE; METABOLISM; STRENGTH;

D O I：

10.1016/j.cmet.2019.06.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Anabolic resistance and impaired myocellular quality contribute to age-related sarcopenia, which exacerbates with obesity. Diet-induced muscle mass loss is attenuated by resistance or aerobic plus resistance exercise compared to aerobic exercise in obese elderly. We assessed chronic effects of weight loss plus different exercise modalities on muscle protein synthesis response to feeding and myocellular quality. Obese older adults were randomized to a weight-management program plus aerobic, resistance, or combined aerobic and resistance exercise or to control. Participants underwent vastus lateralis biopsies at baseline and 6 months. Muscle protein synthesis rate increased more in resistance and combined than in control. Autophagy mediators' expression decreased more in combined than in aerobic, which experienced a higher increase in inflammation and mitochondrial regulators' expression. In obese elderly, combined aerobic and resistance exercise is superior to either mode independently for improving muscle protein synthesis and myocellular quality, thereby maintaining muscle mass during weight-loss therapy.

引用

页码：261 / +

页数：19

共 70 条

[51] Resistance training alters the response of fed state mixed muscle protein synthesis in young man [J].

Tang, Jason E. ;

Perco, Jennifer G. ;

Moore, Daniel R. ;

Wilkinson, Sarah B. ;

Phillips, Stuart M. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2008, 294 (01) :R172-R178

[52]

Templeton GF, 2011, COMMUN ASSOC INF SYS, V28, P41

[53] Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis [J].

Tretter, Laszlo ;

Patocs, Attila ;

Chinopoulos, Christos .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2016, 1857 (08) :1086-1101

[54] Exercise Type in Dieting Obese Older Adults [J].

Stigler, Florian L. ;

Lustig, Robert H. ;

Moser, Adrian M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (06) :598-599

[55] Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults [J].

Villareal, Dennis T. ;

Aguirre, Lina ;

Gurney, A. Burke ;

Waters, Debra L. ;

Sinacore, David R. ;

Colombo, Elizabeth ;

Armamento-Villareal, Reina ;

Qualls, Clifford .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (20) :1943-1955

[56] Effect of Weight Loss on the Rate of Muscle Protein Synthesis During Fasted and Fed Conditions in Obese Older Adults [J].

Villareal, Dennis T. ;

Smith, Gordon I. ;

Shah, Krupa ;

Mittendorfer, Bettina .

OBESITY, 2012, 20 (09) :1780-1786

[57] Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults [J].

Villareal, Dennis T. ;

Chode, Suresh ;

Parimi, Nehu ;

Sinacore, David R. ;

Hilton, Tiffany ;

Armamento-Villareal, Reina ;

Napoli, Nicola ;

Qualls, Clifford ;

Shah, Krupa .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (13) :1218-1229

[58] Regular Multicomponent Exercise Increases Physical Fitness and Muscle Protein Anabolism in Frail, Obese, Older Adults [J].

Villareal, Dennis T. ;

Smith, Gordon I. ;

Sinacore, David R. ;

Shah, Krupa ;

Mittendorfer, Bettina .

OBESITY, 2011, 19 (02) :312-318

[59] Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss - A randomized controlled trial [J].

Villareal, Dennis T. ;

Fontana, Luigi ;

Weiss, Edward P. ;

Racette, Susan B. ;

Steger-May, Karen ;

Schechtman, Kenneth B. ;

Klein, Samuel ;

Holloszy, John O. .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (22) :2502-2510

[60] Physical frailty and body composition in obese elderly men and women [J].

Villareal, DT ;

Banks, M ;

Siener, C ;

Sinacore, DR ;

Klein, S .

OBESITY RESEARCH, 2004, 12 (06) :913-920

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