Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine

被引：52

作者：

Webster, DE

Cooney, ML

Huang, ZJ

Drew, DR

Ramshaw, IA

Dry, IB

Strugnell, RA

Martin, JL

Wesselingh, SL

机构：

[1] Monash Univ, Sch Med, Alfred Hosp, Dept Med, Prahran, Vic 3181, Australia

[2] Monash Univ, Sch Med, Alfred Hosp, Dept Microbiol, Prahran, Vic 3181, Australia

[3] CSIRO, Hort Unit, Glen Osmond, SA 5064, Australia

[4] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

[5] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 15期

关键词：

D O I：

10.1128/JVI.76.15.7910-7912.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.

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收藏

页码：7910 / 7912

页数：3

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