COVID-19 in children: analysis of the first pandemic peak in England

被引：116

作者：

Ladhani, Shamez N. ^{[1
,2
]}

Amin-Chowdhury, Zahin ^{[1
]}

Davies, Hannah G. ^{[1
,2
]}

Aiano, Felicity ^{[1
]}

Hayden, Iain ^{[1
]}

Lacy, Joanne ^{[1
]}

Sinnathamby, Mary ^{[1
]}

de Lusignan, Simon ^{[3
,4
]}

Demirjian, Alicia ^{[4
,5
,6
]}

Whittaker, Heather ^{[7
]}

Andrews, Nick ^{[7
]}

Zambon, Maria ^{[8
]}

Hopkins, Susan ^{[4
]}

Ramsay, Mary Elizabeth ^{[1
,9
]}

机构：

[1] Publ Hlth England, Immunisat & Countermeasures Div, London NW9 5EQ, England

[2] St Georges Univ London, Paediat Infect Dis Res Grp, London, England

[3] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England

[4] Publ Hlth England, Antimicrobial Resistance & Hosp Acquired Infect D, London, England

[5] Evelina London Childrens Hosp, Paediat Infect Dis & Immunol, London, England

[6] Kings Coll London, Fac Life Sci & Med, London, England

[7] Publ Hlth England, Stat Modelling & Econ Dept, London, England

[8] Publ Hlth England, Microbiol Serv Colindale, London, England

[9] London Sch Hyg & Trop Med, London, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2020年 / 105卷 / 12期

关键词：

SURVEILLANCE; INFECTIONS; INFLUENZA;

D O I：

10.1136/archdischild-2020-320042

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives To assess disease trends, testing practices, community surveillance, case-fatality and excess deaths in children as compared with adults during the first pandemic peak in England. Setting England. Participants Children with COVID-19 between January and May 2020. Main outcome measures Trends in confirmed COVID-19 cases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity rates in children compared with adults; community prevalence of SARS-CoV-2 in children with acute respiratory infection (ARI) compared with adults, case-fatality rate in children with confirmed COVID-19 and excess childhood deaths compared with the previous 5 years. Results Children represented 1.1% (1,408/129,704) of SARS-CoV-2 positive cases between 16 January 2020 and 3 May 2020. In total, 540 305 people were tested for SARS-COV-2 and 129,704 (24.0%) were positive. In children aged <16 years, 35,200 tests were performed and 1408 (4.0%) were positive for SARS-CoV-2, compared to 19.1%-34.9% adults. Childhood cases increased from mid-March and peaked on 11 April before declining. Among 2,961 individuals presenting with ARI in primary care, 351 were children and 10 (2.8%) were positive compared with 9.3%-45.5% in adults. Eight children died and four (case-fatality rate, 0.3%; 95% CI 0.07% to 0.7%) were due to COVID-19. We found no evidence of excess mortality in children. Conclusions Children accounted for a very small proportion of confirmed cases despite the large numbers of children tested. SARS-CoV-2 positivity was low even in children with ARI. Our findings provide further evidence against the role of children in infection and transmission of SARS-CoV-2.

引用

页码：1180 / 1185

页数：6

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