Effect of Mesenchymal Stem Cells on the Vascularization of the Artificial Site for Islet Transplantation in Rats

被引：11

作者：

Fabryova, E. ^{[1
]}

Jirak, D. ^{[2
]}

Girman, P. ^{[3
]}

Zacharovova, K. ^{[1
]}

Galisova, A. ^{[2
]}

Saudek, F. ^{[1
,3
]}

Kriz, J. ^{[3
]}

机构：

[1] Inst Clin & Expt Med IKEM, Ctr Expt Med, Prague, Czech Republic

[2] Inst Clin & Expt Med IKEM, Dept MR Spect, Prague, Czech Republic

[3] Inst Clin & Expt Med IKEM, Ctr Diabet, Prague, Czech Republic

来源：

TRANSPLANTATION PROCEEDINGS | 2014年 / 46卷 / 06期

关键词：

TOOL;

D O I：

10.1016/j.transproceed.2014.05.074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An adequate vascularization of the artificially created cavity is crucial for subsequent transplantation of isolated pancreatic islets. In a reported study, dynamic contrast-enhanced magnetic resonance imaging was used to assess the effect of mesenchymal stem cells on neoangiogenesis within connective tissue surrounding an implantable biocompatible device. The signal increase detected after injection of magnetic resonance contrast agent in each target region was considered to be an effect of contrast agent, which was related to the blood supply. To minimize the influence of variability in contrast agent application, all outcomes measured in the implanted devices were normalized to the signal intensity of kidney tissue. When supported by mesenchymal stem cells, the mean signal increase intra-abdominally was 42%, 41%, and 64% and within subcutaneously implanted devices was 23%, 54%, and 52% of that measured in kidney.

引用

页码：1963 / 1966

页数：4

共 10 条

[1] Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site [J].

Carlsson, PO ;

Palm, F ;

Andersson, A ;

Liss, P .

DIABETES, 2001, 50 (03) :489-495

[2] Positron emission tomography: A real-time tool to quantify early islet engraftment in a preclinical large animal model [J].

Eich, Torsten ;

Eriksson, Olof ;

Sundin, Anders ;

Estrada, Sergio ;

Brandhorst, Daniel ;

Brandhorst, Heide ;

Langstrom, Bengt ;

Nilsson, Bo ;

Korsgren, Olle ;

Lundgren, Torbjorn .

TRANSPLANTATION, 2007, 84 (07) :893-898

[3] Bone Marrow-Derived Mesenchymal Stem Cells Improve Islet Graft Function in Diabetic Rats [J].

Figliuzzi, M. ;

Cornolti, R. ;

Perico, N. ;

Rota, C. ;

Morigi, M. ;

Remuzzi, G. ;

Remuzzi, A. ;

Benigni, A. .

TRANSPLANTATION PROCEEDINGS, 2009, 41 (05) :1797-1800

[4]

Guan J, 1995, TRANSPLANT P, V27, P3236

[5] Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation [J].

Johansson, H ;

Lukinius, A ;

Moberg, L ;

Lundgren, T ;

Berne, C ;

Foss, A ;

Felldin, M ;

Källen, R ;

Salmela, K ;

Tibe, A ;

Tufveson, G ;

Ekdahl, KN ;

Elgue, G ;

Korsgren, O ;

Nilsson, B .

DIABETES, 2005, 54 (06) :1755-1762

[6] Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Tool to Monitor the Blood Supply to an Artificial Cavity Used as a Site for Islet Transplantation in Rats [J].

Kriz, J. ;

Jirak, D. ;

Koblas, T. ;

Vilk, G. ;

Girman, P. ;

Hajek, M. ;

Saudek, F. .

TRANSPLANTATION PROCEEDINGS, 2011, 43 (09) :3226-3230

[7] Vascularization of Artificial Beds for Pancreatic Islet Transplantation in a Rat Model [J].

Kriz, J. ;

Jirak, D. ;

Vilk, G. J. ;

Girman, P. ;

White, D. J. ;

Hajek, M. ;

Saudek, F. .

TRANSPLANTATION PROCEEDINGS, 2010, 42 (06) :2097-2101

[8] A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence [J].

Kriz, Jan ;

Vilk, Greg ;

Mazzuca, Delfina M. ;

Toleikis, Philip M. ;

Foster, Paula J. ;

White, David J. G. .

AMERICAN JOURNAL OF SURGERY, 2012, 203 (06) :793-797

[9] The portal immunosuppressive storm - Relevance to islet transplantation? [J].

Shapiro, AMJ ;

Gallant, HL ;

Hao, EG ;

Lakey, JRT ;

McCready, T ;

Rajotte, RV ;

Yatscoff, RW ;

Kneteman, NM .

THERAPEUTIC DRUG MONITORING, 2005, 27 (01) :35-37

[10] Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium [J].

Tang, YL ;

Zhao, Q ;

Zhang, YC ;

Cheng, LL ;

Liu, MY ;

Shi, JH ;

Yang, YZ ;

Pan, CZ ;

Ge, JB ;

Phillips, MI .

REGULATORY PEPTIDES, 2004, 117 (01) :3-10

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