Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

被引：32
作者：
Ingordo, Vito [1 ,12 ]
Cazzaniga, Simone [3 ]
Raone, Beatrice [4 ]
Digiuseppe, Maria Donata [2 ,12 ]
Musumeci, Maria Letizia [5 ,12 ]
Fai, Dario [6 ,12 ]
Pellegrino, Michele [7 ,12 ]
Pezzarossa, Enrico [8 ,12 ]
Di Lernia, Vito [9 ,12 ]
Battarra, Vincenzo Claudio [10 ,12 ]
Sirna, Riccardo [11 ,12 ]
Patrizi, Annalisa [4 ,12 ]
Naldi, Luigi [3 ,12 ]
机构：
[1] SS Annunziata Hosp, Outpatient Dept Dermatol, Hlth Local Unit, Taranto, Italy
[2] SS Annunziata Hosp, Dept Dermatol, Taranto, Italy
[3] Fdn Ric Osped Maggiore, Ctr Studi GISED, Bergamo, Italy
[4] Univ Bologna, Dept Expt Diagnost & Specialized Med, Bologna, Italy
[5] Univ Catania, AOU Policlin Vittorio Emanuele, POG Rodol, Dept Dermatol, Catania, Italy
[6] Romasi Hosp, Outpatient Dept Dermatol, Rome, Italy
[7] Univ Siena, Dept Dermatol, I-53100 Siena, Italy
[8] Ist Ospitalieri Cremona, Dept Dermatol, Cremona, Italy
[9] Arcispedale Santa Maria Nuova IRCCS, Dermatol Unit, Reggio Emilia, Italy
[10] S Sebastiano & S Anna Hosp, Dept Dermatol, Caserta, Italy
[11] Hlth Local Unit Hosp, Dept Dermatol, Grosseto, Italy
[12] ADOI, Dermatoepidemiol & Evidence Based Dermatol Study, Scanzano Ionico, Italy
来源：
DERMATOLOGY | 2014年 / 228卷 / 03期
关键词：
Circulating autoantibodies; Autoimmune comorbidities; Vitiligo; Multicenter Italian study; THYROID-DISEASE; GENERALIZED VITILIGO; CHILDREN; PREVALENCE; ANTIBODIES; ADOLESCENTS; DYSFUNCTION; POPULATION; DISORDERS; INDIA;
D O I：
10.1159/000357807
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: Autoinnmune comorbidities and circulating autoantibodies have been observed in vitiligo patients, but differences in rate are present according to countries in which the studies were performed, perhaps owing to ethnic diversities or different trigger factors. Objective:To estimate the prevalence of circulating autoantibodies and overt autoimmune diseases in a fairly large sample of Italian vitiligo patients. Methods: 175 outpatients affected by vitiligo and referred to nine dermatological centers were included in the study. Patients were offered routine blood test, serological testing for thyroid function and search for autoantibodies. Results: At least one circulating autoantibody was detected in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-thyroglobulin (23.4%), antinuclear antibodies (16.8%) and anti-gastric parietal cell antibodies (7.8%) were the most noticed autoantibodies. 74 (41.5%) autoimmune connorbidities, mainly autoimmune thyroiditis (37%), were reported. Conclusion: The prevalence of autoimmune comorbidities and circulating autoantibodies in this study was in agreement with other surveys conducted on Caucasian patients. (c) 2014 S. Karger AG, Basel
引用
收藏
页码：240 / 249
页数：10
相关论文
共 58 条
  • [1] Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey
    Akay, B. N.
    Bozkir, M.
    Anadolu, Y.
    Gullu, S.
    [J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2010, 24 (10) : 1144 - 1150
  • [2] Epidemiology of vitiligo and associated autoimmune diseases in caucasian probands and their families
    Alkhateeb, A
    Fain, PR
    Thody, A
    Bennett, DC
    Spritz, RA
    [J]. PIGMENT CELL RESEARCH, 2003, 16 (03): : 208 - 214
  • [3] Polyglandular autoimmune diseases in a dermatological clinical setting: vitiligo-associated autoimmune diseases
    Amerio, Paolo
    Di Rollo, Daniela
    Carbone, Angelo
    Auriemma, Matteo
    Marra, Maria Elena
    De Remigis, Pierluigi
    Feliciani, Claudio
    Tracanna, Marco
    Tulli, Antonio
    [J]. EUROPEAN JOURNAL OF DERMATOLOGY, 2010, 20 (03) : 354 - 358
  • [4] AN EPIDEMIOLOGIC CASE-CONTROL STUDY IN A POPULATION WITH VITILIGO
    BARONA, MI
    ARRUNATEGUI, A
    FALABELLA, R
    ALZATE, A
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1995, 33 (04) : 621 - 625
  • [5] VITILIGO IN A BLACK-POPULATION
    BARSKY, S
    KNAPP, DP
    LEVINE, M
    SCHULLERGOLDMAN, S
    [J]. ARCHIVES OF DERMATOLOGY, 1979, 115 (02) : 225 - 225
  • [6] INCIDENCE AND SIGNIFICANCE OF ORGAN-SPECIFIC AUTOIMMUNE DISORDERS (CLINICAL, LATENT OR ONLY AUTOANTIBODIES) IN PATIENTS WITH VITILIGO
    BETTERLE, C
    CARETTO, A
    DEZIO, A
    PEDINI, B
    VELLERFORNASA, C
    CECCHETTO, A
    ACCORDI, F
    PESERICO, A
    [J]. DERMATOLOGICA, 1985, 171 (06): : 419 - 423
  • [7] Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population.: The Health Study of Nord-Trondelag (HUNT)
    Bjoro, T
    Holmen, J
    Krüger, O
    Midthjell, K
    Hunstad, K
    Schreiner, T
    Sandnes, L
    Brochmann, H
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2000, 143 (05) : 639 - 647
  • [8] VITILIGO AND ITS AETIOLOGICAL RELATIONSHIP TO ORGAN-SPECIFIC AUTOIMMUNE DISEASE
    BOR, S
    FEIWEL, M
    CHANARIN, I
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 1969, 81 (02) : 83 - &
  • [9] BROSTOFF J, 1969, LANCET, V2, P177
  • [10] SERUM ANTIBODIES IN VITILIGO PATIENTS
    BYSTRYN, JC
    [J]. CLINICS IN DERMATOLOGY, 1989, 7 (02) : 136 - 145
123456