Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors

被引：59

作者：

Osmaniye, Derya ^{[1
,2
]}

Turkes, Cuneyt ^{[3
]}

Demir, Yeliz ^{[4
]}

Ozkay, Yusuf ^{[1
,2
]}

Beydemir, Sukru ^{[5
,6
]}

Kaplancikli, Zafer A. ^{[1
]}

机构：

[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey

[2] Anadolu Univ, Fac Pharm, Cent Anal Lab, Eskisehir, Turkey

[3] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Biochem, Erzincan, Turkey

[4] Ardahan Univ, Nihat Delibalta Gole Vocat High Sch, Dept Pharm Serv, Ardahan, Turkey

[5] Anadolu Univ, Fac Pharm, Dept Biochem, Eskisehir, Turkey

[6] Rectorate Bilecik Seyh Edebali Univ, TR-11230 Bilecik, Turkey

来源：

ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 08期

关键词：

dithiocarbamate; hCA I; hCA II; methysulfonyl; molecular docking; ACCURATE DOCKING; IN-SILICO; GLIDE; BIOISOSTERISM; SULFONAMIDES; XII; IX;

D O I：

10.1002/ardp.202200132

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate compounds. In addition, CA enzyme inhibitory activities are known in groups such as sulfonamide and methylsulfonyl. For this purpose, in this study, a series of 23 new dithiocarbamate-methylsulfonyl derivatives were synthesized and their CA enzyme inhibitory activities were investigated. The inhibition potentials of the obtained compounds against the human CA I and CA II enzymes were investigated by the in vitro enzyme isolation method. It is seen that the compounds show activity at the nanomolar level. Molecular docking studies of the compounds were carried out by in silico methods. The poses of compounds 2a, 2e, 2o, and 2t are presented.

引用

页数：15

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