Copper( II)-Catalyzed Aerobic Oxidative Coupling between Chalcone and 2-Aminopyridine via C HAmination:AnExpedientSynthesis of 3-AroylimidazoACHTUNGTRENUNG[ 1,2-a] pyridines

被引：107

作者：

Monir, Kamarul ^{[1
]}

Bagdi, Avik Kumar ^{[1
]}

Mishra, Subhajit ^{[1
]}

Majee, Adinath ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 05期

关键词：

aerobic oxidative amination; 3-aroylimidazo[1; 2-a]pyridines; chalcones; copper(II) acetate; regioselectivity; N BOND FORMATION; ONE-POT SYNTHESIS; CATALYZED DIRECT AMINATION; H ACTIVATION REACTIONS; BETA-KETO-ESTERS; ANTIVIRAL AGENTS; TERMINAL ALKYNES; SINGLE-ELECTRON; DIRECT ACCESS; FUNCTIONALIZATION;

D O I：

10.1002/adsc.201300900

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple and efficient protocol has been developed for the synthesis of 3-aroylimidazopyridines via copper(II) acetate-catalyzed aerobic oxidative amination. A library of 3-aroylimidazopyridines was synthesized from readily accessible chalcones and 2-aminopyridines with high yields and regioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.

引用

页码：1105 / 1112

页数：8

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