Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)

被引：339

作者：

Soria, Francesco ^{[1
,2
]}

Shariat, Shahrokh F. ^{[1
,3
,4
,5
]}

Lerner, Seth P. ^{[6
]}

Fritsche, Hans-Martin ^{[7
]}

Rink, Michael ^{[8
]}

Kassouf, Wassim ^{[9
]}

Spiess, Philippe E. ^{[10
]}

Lotan, Yair ^{[4
]}

Ye, Dingwei ^{[11
]}

Fernandez, Mario I. ^{[12
]}

Kikuchi, Eiji ^{[13
]}

Chade, Daher C. ^{[14
,15
]}

Babjuk, Marko ^{[16
]}

Grollman, Arthur P. ^{[17
,18
]}

Thalmann, George N. ^{[19
]}

机构：

[1] Med Univ Vienna, Dept Urol, Vienna, Austria

[2] Univ Studies Torino, San Giovanni Battista Hosp, Dept Surg Sci, Div Urol, Turin, Italy

[3] Karl Landsteiner Inst Urol & Androl, Vienna, Austria

[4] Univ Texas Southwestern Med Ctr, Dept Urol, Dallas, TX USA

[5] Weill Cornell Med Coll, Dept Urol, New York, NY USA

[6] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA

[7] Univ Regensburg, Caritas St Josef Med Ctr, Dept Urol, Regensburg, Germany

[8] Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany

[9] McGill Univ, Dept Surg Urol, Montreal, PQ, Canada

[10] H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Oncol, Tampa, FL USA

[11] Fudan Univ, Shanghai Canc Ctr, Dept Urol, Shanghai, Peoples R China

[12] Clin Alemana, Dept Urol, Santiago, Chile

[13] Keio Univ, Sch Med, Dept Urol, Tokyo, Japan

[14] Univ Sao Paulo, Sch Med, Dept Urol, Sao Paulo, Brazil

[15] Inst Canc Res, Sao Paulo, Brazil

[16] Charles Univ Praha, Fac Med 2, Fac Hosp Motol, Dept Urol, Prague, Czech Republic

[17] SUNY Stony Brook, Dept Pharmacol Sci, Stony Brook, NY 11794 USA

[18] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA

[19] Univ Hosp Bern, Dept Urol, Bern, Switzerland

来源：

WORLD JOURNAL OF UROLOGY | 2017年 / 35卷 / 03期

关键词：

UTUC; Epidemiology; Risk factor; Diagnosis; New technologies; Predictive tools; Prognosis; UPPER URINARY-TRACT; URETEROSCOPIC BIOPSY; CELL CARCINOMAS; RADICAL NEPHROURETERECTOMY; INTRAVESICAL RECURRENCE; ONCOLOGIC OUTCOMES; RENAL PELVIS; IMPACT; SMOKING; TUMORS;

D O I：

10.1007/s00345-016-1928-x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment. Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance. UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed. Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.

引用

页码：379 / 387

页数：9

共 60 条

[1] Preoperative Hydronephrosis, Ureteroscopic Biopsy Grade and Urinary Cytology Can Improve Prediction of Advanced Upper Tract Urothelial Carcinoma [J].