Significance of Decoy Receptor 3 and IFN-γ/IL-4 in Peripheral Blood of Rheumatoid Arthritis Patient

To investigate DcR3 Levels of peripheral blood in rheumatoid arthritis(RA), and analyzes the correlation between the DcR3 Levels of Peripheral Blood and the Disease Activity in Rheumatoid Arthritis Patient.The expression levels of DcR3 mRNA in peripheral Blood monocytes of 80 RA patients and 50 healthy controls were detected by real-time polymerase chain reaction, the levels of DcR3, IL-4 and IFN-gamma in serum were detected by ELISA(enzyme-linked immuno sorbent assay). The expression levels of DcR3 mRNA of active stage in RA patients were higher than that of remission stage in RA patients and healthy controls(P<0.05); The levels of DcR3, IFN-gamma and IFN-y/IL-4 of active stage in RA patients were higher than that of remission stage in RA patients and healthy controls(P<0.01); The correlationships between DcR3 mRNA levels, IFN-gamma/IL-4 and active renal score (DAS28)show positive correlation.The expression levels of peripheral blood DcR3 does significant increase in RA active patients and it is closely related with the activity of the disease which suggesting that DcR3 migh involved in the pathological process.