Common Epidemiology of Rickettsia felis Infection and Malaria, Africa

被引：87

作者：

Mediannikov, Oleg ^{[1
,2
]}

Socolovschi, Cristina ^{[1
]}

Edouard, Sophie ^{[1
]}

Fenollar, Florence ^{[1
,2
]}

Mouffok, Nadjet ^{[3
]}

Bassene, Hubert ^{[2
]}

Diatta, Georges ^{[2
]}

Tall, Adama ^{[4
]}

Niangaly, Hamidou ^{[5
]}

Doumbo, Ogobara ^{[5
]}

Lekana-Douki, Jean Bernard ^{[6
,7
]}

Znazen, Abir ^{[8
]}

Sarih, M'hammed ^{[9
]}

Ratmanov, Pavel ^{[1
,10
]}

Richet, Herve ^{[1
]}

Ndiath, Mamadou O. ^{[2
]}

Sokhna, Cheikh ^{[2
]}

Parola, Philippe ^{[1
]}

Raoult, Didier ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, Fac Med, Marseille, France

[2] Inst Rech Dev, Dakar, Senegal

[3] Ctr Hosp Univ Oran, Oran, Algeria

[4] Inst Pasteur, Dakar, Senegal

[5] Univ Sci Tech & Technol, Bamako, Mali

[6] Ctr Int Rech Med Franceville, Unite Parasitol Med, Franceville, Gabon

[7] Univ Sci Sante Libreville, Libreville, Gabon

[8] Habib Bourguiba Univ Hosp, Sfax, Tunisia

[9] Inst Pasteur Maroc, Casablanca, Morocco

[10] Far Eastern State Med Univ, Khabarovsk, Russia

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 11期

关键词：

RELAPSING FEVER; SURVEILLANCE; BACTEREMIA; MOSQUITOS; FELLS; PCR;

D O I：

10.3201/eid1911.130361

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study aimed to compare the epidemiology of Rickettsia felis infection and malaria in France, North Africa, and sub-Saharan Africa and to identify a common vector. Blood specimens from 3,122 febrile patients and from 500 nonfebrile persons were analyzed for R. felis and Plasmodium spp. We observed a significant linear trend (p<0.0001) of increasing risk for R. felis infection. The risks were lowest in France, Tunisia, and Algeria (1%), and highest in rural Senegal (15%). Co-infections with R. felis and Plasmodium spp. and occurrences of R. felis relapses or reinfections were identified. This study demonstrates a correlation between malaria and R. felis infection regarding geographic distribution, seasonality, asymptomatic infections, and a potential vector. R. felis infection should be suspected in these geographical areas where malaria is endemic. Doxycycline chemoprophylaxis against malaria in travelers to sub-Saharan Africa also protects against rickettsioses; thus, empirical treatment strategies for febrile illness for travelers and residents in sub-Saharan Africa may require reevaluation.

引用

页码：1775 / 1783

页数：9

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