Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3

被引：38
作者：
Willnow, TE
Nykjaer, A
机构：
[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
[2] Free Univ Berlin, Fac Med, D-1000 Berlin, Germany
[3] Aarhus Univ, Dept Biochem Med, Aarhus, Denmark
来源：
CURRENT OPINION IN LIPIDOLOGY | 2002年 / 13卷 / 03期
关键词：
D O I：
10.1097/00041433-200206000-00004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Steroid hormones are believed to enter cells solely by free diffusion through the plasma membrane. However, recent work on the uptake of 25-hydroxyvitamin D-3 into the kidney has identified an endocytic pathway that is responsible for the delivery of this steroid to renal tissues. This finding led to a new perception that endocytosis may play an important role in the cell-type-specific targeting and uptake of steroid hormones. In the present review, we describe the molecular components (e.g. steroid carriers, enclocytic receptors and intracellular transport proteins) that constitute this novel pathway for tissue-specific uptake of vitamin D metabolites. Curr Opin Lipidol 13:255-260, (C) 2002 Lippincott Williams Wilkins.
引用
收藏
页码：255 / 260
页数：6
相关论文
共 45 条
[1]   Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1 [J].
Aminoff, M ;
Carter, JE ;
Chadwick, RB ;
Johnson, C ;
Gräsbeck, R ;
Abdelaal, MA ;
Broch, H ;
Jenner, LB ;
Verroust, PJ ;
Moestrup, SK ;
de la Chapelle, A ;
Krahe, R .
NATURE GENETICS, 1999, 21 (03) :309-313
[2]  
Birn H, 2000, J AM SOC NEPHROL, V11, P191, DOI 10.1681/ASN.V112191
[3]   Regulation of vitamin D-1α-hydroxylase in a human cortical collecting duct cell line [J].
Bland, R ;
Zehnder, D ;
Hughes, SV ;
Ronco, PM ;
Stewart, PM ;
Hewison, M .
KIDNEY INTERNATIONAL, 2001, 60 (04) :1277-1286
[4]   A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney [J].
Burmeister, R ;
Boe, IM ;
Nykjaer, A ;
Jacobsen, C ;
Moestrup, SK ;
Verroust, P ;
Christensen, EI ;
Lund, J ;
Willnow, TE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) :13295-13301
[5]  
CHRISTENSEN EI, 1995, EUR J CELL BIOL, V66, P349
[6]  
Christensen EI, 1999, J AM SOC NEPHROL, V10, P2224
[7]   ELECTRON-MICROSCOPE AUTORADIOGRAPHIC EVIDENCE OF INVIVO ANDROGEN-BINDING PROTEIN INTERNALIZATION IN THE RAT EPIDIDYMIS PRINCIPAL CELLS [J].
GERARD, A ;
KHANFRI, J ;
GUEANT, JL ;
FREMONT, S ;
NICOLAS, JP ;
GRIGNON, G ;
GERARD, H .
ENDOCRINOLOGY, 1988, 122 (04) :1297-1307
[8]   ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells [J].
Günther, W ;
Lüchow, A ;
Cluzeaud, F ;
Vandewalle, A ;
Jentsch, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8075-8080
[9]   IDENTIFICATION OF THE STEROL-BINDING AND ACTIN-BINDING DOMAINS OF PLASMA VITAMIN-D BINDING-PROTEIN (GC-GLOBULIN) [J].
HADDAD, JG ;
HU, YZ ;
KOWALSKI, MA ;
LARAMORE, C ;
RAY, K ;
ROBZYK, P ;
COOKE, NE .
BIOCHEMISTRY, 1992, 31 (31) :7174-7181
[10]   PLASMA VITAMIN-D-BINDING PROTEIN (GC-GLOBULIN) - MULTIPLE TASKS [J].
HADDAD, JG .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1995, 53 (1-6) :579-582
12345