Motualevic Acids A-F, Antimicrobial Acids from the Sponge Siliquariaspongia sp.

被引：63

作者：

Keffer, Jessica L. ^{[1
]}

Plaza, Alberto ^{[1
]}

Bewley, Carole A. ^{[1
]}

机构：

[1] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 05期

关键词：

FATTY-ACIDS; MARINE; AZACYCLOPROPENE; DEPSIPEPTIDES; AZIRINOMYCIN; CHALLENGES; DRUGS;

D O I：

10.1021/ol802890b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seven new antibacterials, motualevic acids A-F (1-6) and (4E)-(R)-antazirine (7), have been isolated from the marine sponge Siliquariaspongia sp. and their structures elucidated by spectroscopic methods. Motualevic acids A-D are the first glycyl conjugates of the omega-brominated lipid (E)-14,14-dibromotetradeca-2,13-dienoic acid, and motualevic acid F Is the first long-chain 2H-azirine 2-carboxylic acid to be found in nature. Carboxylic acid-containing compounds 1 and 6 inhibit the growth of Staphylococcus aureus and methicillin-resistant S. aureus at 1.2-10.9 mu g/mL.

引用

页码：1087 / 1090

页数：4

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