Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

被引：21

作者：

Noorlag, Rob ^{[1
]}

Boeve, Koos ^{[2
,4
]}

Witjes, Max J. H. ^{[2
]}

Koole, Ronald ^{[1
]}

Peeters, Ton L. M. ^{[3
]}

Schuuring, Ed ^{[4
]}

Willems, Stefan M. ^{[3
]}

van Es, Robert J. J. ^{[5
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Oral & Maxillofacial Surg, Utrecht, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands

[3] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol, Groningen, Netherlands

[5] Univ Med Ctr Utrecht, Ctr Canc, Dept Head & Neck Surg Oncol, G-05-221,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 02期

关键词：

CCND1; cyclin D1; early oral cancer; occult nodal metastasis; biomarker; SQUAMOUS-CELL CARCINOMA; MESSENGER-RNA LEVELS; NECK DISSECTION; MULTICENTER TRIAL; COPY NUMBER; EXPRESSION; BIOPSY; HEAD; GENE; MANAGEMENT;

D O I：

10.1002/hed.24584

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited. Methods. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases. Results. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers. Conclusion. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. (C) 2016 Wiley Periodicals, Inc.

引用

页码：326 / 333

页数：8

共 32 条

[1] Sentinel Node Biopsy in Head and Neck Squamous Cell Cancer: 5-Year Follow-Up of a European Multicenter Trial [J].

Alkureishi, Lee W. T. ;

Ross, Gary L. ;

Shoaib, Taimur ;

Soutar, David S. ;

Robertson, A. Gerry ;

Thompson, Richard ;

Hunter, Keith D. ;

Sorensen, Jens A. ;

Thomsen, Jorn ;

Krogdahl, Annelise ;

Alvarez, Julio ;

Barbier, Luis ;

Santamaria, Joseba ;

Poli, Tito ;

Sesenna, Enrico ;

Kovacs, Adorjan F. ;

Gruenwald, Frank ;

Barzan, Luigi ;

Sulfaro, Sandro ;

Alberti, Franco .

ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (09) :2459-2464

[2] Intratumor Heterogeneity and Precision of Microarray-Based Predictors of Breast Cancer Biology and Clinical Outcome [J].

Barry, William T. ;

Kernagis, Dawn N. ;

Dressman, Holly K. ;

Griffis, Ryan J. ;

Hunter, J'Vonne D. ;

Olson, John A. ;

Marks, Jeff R. ;

Ginsburg, Geoffrey S. ;

Marcom, Paul K. ;

Nevins, Joseph R. ;

Geradts, Joseph ;

Datto, Michael B. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (13) :2198-2206

[3] Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer [J].

D'Cruz, Anil K. ;

Vaish, Richa ;

Kapre, Neeti ;

Dandekar, Mitali ;

Gupta, Sudeep ;

Hawaldar, Rohini ;

Agarwal, Jai Prakash ;

Pantvaidya, Gouri ;

Chaukar, Devendra ;

Deshmukh, Anuja ;

Kane, Shubhada ;

Arya, Supreeta ;

Ghosh-Laskar, Sarbani ;

Chaturvedi, Pankaj ;

Pai, Prathamesh ;

Nair, Sudhir ;

Nair, Deepa ;

Badwe, Rajendra .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (06) :521-529

[4] Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma [J].

de Bree, Remco ;

Takes, Robert P. ;

Castelijns, Jonas A. ;

Medina, Jesus E. ;

Stoeckli, Sandro J. ;

Mancuso, Anthony A. ;

Hunt, Jennifer L. ;

Rodrigo, Juan P. ;

Triantafyllou, Asterios ;

Teymoortash, Afshin ;

Civantos, Francisco J. ;

Rinaldo, Alessandra ;

Pitman, Karen T. ;

Hamoir, Marc ;

Robbins, K. Thomas ;

Silver, Carl E. ;

Hoekstra, Otto S. ;

Ferlito, Alfio .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (12) :1829-1839

[5] Poor Correlation of Histologic Parameters Between Biopsy and Resection Specimen in Early Stage Oral Squamous Cell Carcinoma [J].

Dik, Eric A. ;

Ipenburg, Norbertus A. ;

Adriaansens, Sven O. ;

Kessler, Peter A. ;

van Es, Robert J. ;

Willems, Stefan M. .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2015, 144 (04) :659-666

[6] Sentinel lymph node biopsy in clinically N0 T1-T2 staged oral cancer: The Dutch multicenter trial [J].

Flach, Geke B. ;

Bloemena, E. ;

Klop, W. Martin C. ;

van Es, Robert J. J. ;

Schepman, Kees-Pieter ;

Hoekstra, Otto S. ;

Castelijns, Jonas A. ;

Leemans, C. Rene ;

de Bree, Remco .

ORAL ONCOLOGY, 2014, 50 (10) :1020-1024

[7] Cortactin expression predicts poor survival in laryngeal carcinoma [J].

Gibcus, J. H. ;

Mastik, M. F. ;

Menkema, L. ;

de Bock, G. H. ;

Kluin, Ph M. ;

Schuuring, Ed ;

van der Wal, J. E. .

BRITISH JOURNAL OF CANCER, 2008, 98 (05) :950-955

[8] Amplicon mapping and expression profiling identify the fas-associated death domain gene as a new driver in the 11q13.3 amplicon in Laryngeal/Pharyngeal cancer [J].

Gibcus, Johan H. ;

Menkema, Lorian ;

Mastik, Mirjarn F. ;

Hermsen, MarioA. ;

de Bock, Geertruida H. ;

van Velthuysen, Marie-Louise F. ;

Takes, Robert P. ;

Kok, Klaas ;

Marcos, Cesar A. Alvarez ;

van der Laan, Bernard F. A. M. ;

van den Brekel, Michiel W. M. ;

Langendijk, Johannes A. ;

Kluin, Philip M. ;

van der Wal, Jacqueline E. ;

Schuuring, Ed .

CLINICAL CANCER RESEARCH, 2007, 13 (21) :6257-6266

[9] Management of the N0 neck in early stage oral squamous cell cancer: A modeling study of the cost-effectiveness [J].

Govers, Tim M. ;

Takes, Robert P. ;

Karakullukcu, M. Baris ;

Hannink, Gerjon ;

Merkx, Matthias A. W. ;

Grutters, Janneke P. C. ;

Rovers, Maroeska M. .

ORAL ONCOLOGY, 2013, 49 (08) :771-777

[10] Comparing ERCC1 protein expression, mRNA levels, and genotype in squamous cell carcinomas of the head and neck treated with concurrent chemoradiation stratified by HPV status [J].

Hao, Desiree ;

Lau, Harold Y. ;

Eliasziw, Misha ;

Box, Alan ;

Diaz, Roman ;

Klimowicz, Alexander C. ;

Shin, Brian ;

Lees-Miller, Susan P. ;

Magliocco, Anthony M. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2012, 34 (06) :785-791

← 1 2 3 4 →