Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: Serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults

被引:62
|
作者
Jain, Ram B. [1 ]
Ducatman, Alan [1 ]
机构
[1] West Virginia Univ, Sch Publ Hlth, Morgantown, WV USA
关键词
Perfluoroalkyl acids; Perfluorooctanoic acid; Glomerular function; Serum and urine albumin; Serum and urine creatinine; GLUCOSE-HOMEOSTASIS; PERFLUOROOCTANOIC ACID; SUBSTANCES; PFOA; ELIMINATION; ACCUMULATION; ASSOCIATION; EXPOSURE; EQUATION; ISOMERS;
D O I
10.1016/j.envres.2019.04.034
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Associations between selected perfluoroalkyl acids (PFAAs) and biomarkers of renal function were evaluated for US adult aged >= 20 years (N = 8220) in the National Health and Nutrition Examination Survey for 2005-2014. Glomerular filtration (GF) stage-stratified regression models were classified by estimated glomerular filtration rate (eGFR) with GF-1 (eGFR > 90 mL/min/1.73 m(2)), GF-2 (eGFR 60-89 mL/min/1.73 ma), GF-3A (45-59 mL/min/1.73 m(2)), and GF-3B/4 (15-44 mL/min/1.73 m(2)). For GF-1, PFOA, PFOS, and PFHxS were positively and significantly associated with serum creatinine. Serum albumin levels were positively associated with the PFAA considered at all stages and most associations were significant. Further, PFAS serum concentration associations to serum albumin were about 2-3 times stronger at GF-3B/4 than at GF-1. In contrast, urine albumin was negatively and significantly associated with PFOA and PFHxS serum concentrations at all stages of renal function, while, PFOS and PFNA were negatively and significantly associated to urine albumin at GF-3A and GF-3B/4. Urine albumin/creatinine ratios were negatively and significantly associated with PFOA, PFOS, and, and PFHxS serum concentrations at all stages of renal function, as well as with PFNA and PFDA at GF-3A and GF-3B/4. Recent work revealed that serum PFAAs have an inverted U-shaped association to the calculated stages of renal failure based on eGFR; this work adds that albuminuria makes additional negative contributions to already existing negative associations of PFAA to eGFR in advancing stages of renal failure. We hypothesize that both progressive renal failure per se and especially renal failure with albuminuria cause the kidneys to reabsorb less and to excrete more of the PFAAs studied. We suspect this finding may generalize to some other perfluoroalkyl substances (PFAS). The findings also imply study design considerations for evaluating associations to diseases and biomarkers associated with renal failure, such as diabetes.
引用
收藏
页码:143 / 151
页数:9
相关论文
共 31 条
  • [2] Concentrations of bisphenol A and its associations with urinary albumin creatinine ratios across the various stages of renal function
    Ram B. Jain
    Environmental Science and Pollution Research, 2021, 28 : 9946 - 9953
  • [3] THE RELATIONSHIP OF URINE ALBUMIN CREATININE RATIO, SERUM INFLAMMATORY FACTORS AND DIABETIC RETINOPATHY
    Chen Yanming
    He Shengqing
    Qian Xiaoxian
    HEART, 2011, 97
  • [4] SERUM AND URINE B2-MICROGIOBULIN. CREATININE AND ALBUMIN IN PATIENTS WITH RENAL DISEASE
    胡明淑
    张庆怡
    陈梅芳
    冯亚民
    Journal of Shanghai Second Medical University, 1988, (02) : 27 - 31
  • [5] The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease
    Eguvbe, Augustine Onovuakpo
    Nwagu, Marcellinus Uchechukwu
    Idogun, Eshiotseme Sylvester
    Akande, Adeyinka Abdulrasaq
    UNIVERSA MEDICINA, 2019, 38 (03) : 172 - 178
  • [6] Relationship of Serum Triglycerides with Incident End Stage Renal Disease Across Urine Albumin-to-Creatinine Ratio Subgroups and Chronic Kidney Disease Stages
    Arif, Yousif
    Soohoo, Melissa
    Rizk, John
    Hashemi, Leila
    Marroquin, Maria
    Hsiung, Jui-Ting
    Edward, Jessica
    Streja, Elani
    CIRCULATION, 2021, 144
  • [7] Low Serum Albumin and High Urine Albumin Are Associated with Poorer Subjective Visual Function in US Adults
    Oskardmay, A.
    Shortell, J.
    Laux, J.
    Yang, Y.
    Chesnutt, D.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2017, 65 : S221 - S221
  • [8] Sparse panels of biomarkers in serum and urine predict rapid progression of renal disease in type 1 diabetes and out perform albumin creatinine ratio
    Colombo, M.
    McGurnaghan, S.
    Thoma, I.
    Dunger, D.
    Dalton, N.
    McKeigue, P. M.
    Colhoun, H. M.
    DIABETOLOGIA, 2019, 62 : S31 - S31
  • [9] Urinary Albumin-Creatinine Ratio, Estimated Glomerular Filtration Rate, and All-Cause Mortality Among US Adults With Obstructive Lung Function
    Ford, Earl S.
    CHEST, 2015, 147 (01) : 56 - 67
  • [10] Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes
    Colombo, Marco
    McGurnaghan, Stuart J.
    Blackbourn, Luke A. K.
    Dalton, R. Neil
    Dunger, David
    Bell, Samira
    Petrie, John R.
    Green, Fiona
    MacRury, Sandra
    McKnight, John A.
    Chalmers, John
    Collier, Andrew
    McKeigue, Paul M.
    Colhoun, Helen M.
    DIABETOLOGIA, 2020, 63 (04) : 788 - 798