Ruthenium(II) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

被引：41
作者：
Knezevic, Nikola Z. [1 ]
Stojanovic, Vanja [2 ]
Chaix, Arnaud [1 ]
Bouffard, Elise [2 ]
El Cheikh, Khaled [2 ]
Morere, Alain [2 ]
Maynadier, Marie [3 ]
Lemercier, Gilles [4 ]
Garcia, Marcel [2 ]
Gary-Bobo, Magali [2 ]
Durand, Jean-Olivier [1 ]
Cunin, Frederique [1 ]
机构：
[1] Ecole Natl Super Chim Montpellier, Inst Charles Gerhardt Montpellier, CNRS, UMR5253,ENSCM,UM2,UM1, 8 Rue Ecole Normale, F-34296 Montpellier, France
[2] CNRS, Inst Biomol Max Mousseron, UMR 5247, UM1,UM2, 15 Ave Charles Flahault,BP 14491, F-34093 Montpellier 05, France
[3] NanoMedSyn, 15 Ave Charles Flahault,BP 14491, F-34093 Montpellier 05, France
[4] CNRS, UMR 7312, Inst Chim Mol Reims, BP 1039, F-51687 Reims, France
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 07期
关键词：
POLYPYRIDYL COMPLEXES; CARBON NANOTUBE; DRUG-DELIVERY; SINGLE; NANOCOMPOSITES; LUMINESCENT;
D O I：
10.1039/c5tb02726h
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Multifunctionalized porous silicon nanoparticles (pSiNPs), containing the novel Ru(II) complex-photosensitizer, the polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed and showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) and imaging of cancer. Exposure to NIR light leads to two-photon excitation of the Ru(II)-complex which allows efficient simultaneous cancer-imaging and targeted PDT therapy with the functionalized biodegradable pSiNP nanocarriers.
引用
收藏
页码：1337 / 1342
页数：6
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